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Cutaneous allodynia (pronounced q-tane-ee-us all-o-din-ee-a) is common in migraine. It is a heightened skin sensitivity during an active migraine attack. Migraine attacks in patients who experience allodynia are more difficult to treat. This study intends to collect and evaluate data on the phenomenon of allodynia in patients with episodic migraine during an actual attack. The results of this study may help clinicians better understand allodynia, thereby helping them diagnose and more effectively manage patients with migraine and allodynia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Episodic migraineurs | Eligible subjects with episodic migraine (with or without aura) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention: We are testing for the presence of allodynia | Other | We are testing for the presence of abnormal sensation (allodynia) during a migraine attack. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of Subjects With Allodynia During a Migraine Attack | Brush allodynia (discomfort with normal sensation) measured at pre-specified sites on the head, neck and forearms using a 100 mm visual analog scale (VAS). After each series of brushes the patient will be asked to rate the level of discomfort from "normal sensation" to "extremely painful or unpleasant" using a 100 mm visual analog scale (VAS). | allodynia assessed within 4 hours from onset of migraine head pain |
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Inclusion Criteria:
Exclusion Criteria:
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Subjects with episodic migraine, as defined by the International Headache Society,recruited from our office practice and the communitiy
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| Name | Affiliation | Role |
|---|---|---|
| Abraham A Ashkenazi, M.D. | Jefferson Headache Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jefferson Headache Center | Philadelphia | Pennsylvania | 19107 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Episodic Migraineurs | Eligible subjects with episodic migraine (with or without aura) |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Episodic Migraineurs | Eligible subjects with episodic migraine (with or without aura) |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Proportion of Subjects With Allodynia During a Migraine Attack | Brush allodynia (discomfort with normal sensation) measured at pre-specified sites on the head, neck and forearms using a 100 mm visual analog scale (VAS). After each series of brushes the patient will be asked to rate the level of discomfort from "normal sensation" to "extremely painful or unpleasant" using a 100 mm visual analog scale (VAS). | Participants who completed allodynia test | Posted | Number | participants | allodynia assessed within 4 hours from onset of migraine head pain |
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Episodic Migraineurs | Eligible subjects with episodic migraine (with or without aura) |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Abraham A. Ashkenazi, M.D./Principal Investigator | Doylestown Hospital, Pennsylvania | 215-625-2894 | aashkenzai2001@yahoo.com |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Units |
|---|
| Counts |
|---|
| Participants |
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| 0 |
| 28 |
| 0 |
| 28 |
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| D009422 | Nervous System Diseases |