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The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation, auditory stimulation and a mathematical challenge), and recording sympathetic skin response in the facial area.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Healthy volunteers will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress |
| |
| Left headache | Migraine patients with mostly left sided headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress |
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| Right headache | Migraine patients with mostly right sided headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress |
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| Bilateral headache | Migraine patients without a dominant side headache will be exposed to pain stimulation, visual stimulation, auditory stimulation and mental stress |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pain stimulation | Other | Pain will be simulated with an electric shock 25 mlAMP over the median nerve |
|
| Measure | Description | Time Frame |
|---|---|---|
| Defining sympathetic skin response in migraineurs | Outcome will be presented as mean sympathetic response values for all the different stimuli and then separately for each stimuli | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Defining differences between sympathetic skin response in migraineurs | Outcome will be presented as mean sympathetic response values for all the different stimuli and then separately for each stimuli | One year |
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Inclusion Criteria:
Exclusion Criteria:
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Patients suffering migraine attending our Neurology Clinic and healthy volunteers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erel Domany, MD | Contact | 972-52-6134235 | erel.domany@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Yaron River, MD | Hillel Yaffe Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| ID | Term |
|---|---|
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D010775 | Photic Stimulation |
| D000161 | Acoustic Stimulation |
| ID | Term |
|---|---|
| D010812 | Physical Stimulation |
| D008919 | Investigative Techniques |
| D013812 | Therapeutics |
| D026421 | Sensory Art Therapies |
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| Visual stimulation | Other | Visual stimulation will be performed by a flicker of light on a computer screen at 15 Hrz for 0.3 seconds |
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| Auditory stimulation | Other | Auditory stimulation will be delivered through headphones with a sound at 500 Hrz at 85 decibels for 0.3 seconds |
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| Mental stress | Other | A mathematical challenge will be displayed on a computer screen that must be quickly solved |
|
| D009422 | Nervous System Diseases |
| D000529 |
| Complementary Therapies |