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NCT07742826

Overview

NCT ID: NCT07742826
Lead Sponsor: Final International UniversityOTHER
Official Title: Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery
Brief Summary: This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.
Conditions: Impacted Mandibular Third Molar Extraction

Status and Timeline

Status: Recruiting
Last Update Posted: Aug 3, 2026Actual
Start Date: Sep 3, 2024Actual
Primary Completion Date: Aug 2026Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Patients aged 18 years and older.

Patients with good general health

Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable)

Patients willing and able to attend all postoperative follow-up visits

Exclusion Criteria:

Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency).

Pregnant or breastfeeding women.

Patients with acute infection, abscess, or pericoronitis at the surgical site.

Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications.

Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates.

Patients with bleeding disorders.

Patients with previous radiotherapy to the head and neck region.

Patients unable or unwilling to comply with the study protocol or attend follow-up visits.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 60Estimated
Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Single

Contacts and Locations

Central Contacts: Meliz Kneebone, DDSContact
meliz-95@hotmail.com+905338425731

Similar Studies

Participant Group/Arms

Standard Postoperative Treatment (Control)Active Comparator

Participants receive standard postoperative treatment following impacted mandibular third molar surgery, including amoxicillin/clavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash. No platelet-rich fibrin (PRF) or corticosteroid is administered.

Drug: Amoxicillin/Clavulanic Acid

Drug: Paracetamol

Drug: Chlorhexidine

Platelet-Rich Fibrin (PRF)Experimental

Participants receive platelet-rich fibrin (PRF) placed into the extraction socket in addition to standard postoperative treatment consisting of amoxicillin/clavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash following impacted mandibular third molar surgery.

Biological: Platelet-rich fibrin (PRF)

Platelet-Rich Fibrin Plus CorticosteroidExperimental

Participants receive platelet-rich fibrin (PRF) placement into the extraction socket followed by intramuscular corticosteroid administration, in addition to standard postoperative treatment consisting of amoxicillin/clavulanic acid (Augmentin), paracetamol, and chlorhexidine mouthwash following impacted mandibular third molar surgery.

Biological: Platelet-rich fibrin (PRF)