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The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial.
The present study aims to analyze the effect of PRF (Platelet-rich-fibrin) in terms of facial swelling, trismus and pain after surgical removal of mandibular third molar (M3M) in a split-mouth randomized controlled clinical trial. Facial swelling will be assessed using an innovative three-dimensional digital technique.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test Group | Experimental | Placement of PRF in the post-extraction socket after third molar surgery |
|
| Control Group | No Intervention | No positioning PRF in the post-extraction socket after third molar surgery |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PRF | Biological | Post-operative PRF placement in the post-extraction socket after third molar surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Facial swelling qualitative analysis | To compare the effectiveness of PRF in reducing facial swelling using qualitative three-dimensional analysis (measured by colorimetric variation given by the overlapping volumes) . | Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery |
| Facial swelling quantitative analysis - volumetric differences | To compare the effectiveness of PRF in reducing facial swelling using quantitative three-dimensional analysis ( volumes measured in cm3) . | Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery |
| Facial swelling quantitative analysis - linear differences | To compare the effectiveness of PRF in reducing facial swelling using quantitative three-dimensional analysis (linear differences measured in cm2) . | Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Trismus analysis | To assess the effects of PRF administration on trismus (measured in cm) | Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery |
| Pain analysis with Visual analogue scale (VAS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Magna Graecia University of Catanzaro | Catanzaro | 88100 | Italy |
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| ID | Term |
|---|---|
| D014095 | Tooth, Impacted |
| D014084 | Tooth Avulsion |
| ID | Term |
|---|---|
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
| D018677 | Tooth Injuries |
| D014947 | Wounds and Injuries |
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To assess the effects of PRF administration on pain (measured by VAS-score from 0 to 10 point, with 10 as the worst outcome)
| Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery |