Active, not recruitingInterventionalNot ApplicableLast updated Aug 14, 2026

Platelet-Rich Fibrin as an Antibiotic Delivery Vehicle in Mandibular Third Molar Surgery

Effects of Antibiotic-Prepared Platelet-Rich Fibrin on Postoperative Recovery After Mandibular Third Molar Surgery: A Randomized Split-Mouth Clinical Trial

Overview

ClinicalTrials.gov ID: NCT07764757
Lead Sponsor: Amerigo GiudiceOTHER
Brief Summary: The present study aims to evaluate the effect of platelet-rich fibrin (PRF) used as a local antibiotic delivery vehicle on postoperative outcomes, including facial swelling, trismus, and pain, following mandibular third molar surgery in a randomized split-mouth clinical trial.
Study Type: Interventional

Status

Overall Status: Active, not recruiting
Start Date: Nov 1, 2025Actual
Primary Completion Date: Sep 1, 2026Estimated
Completion Date: Nov 20, 2026Estimated

Study Record Dates

First Submitted: Aug 10, 2026
First Submitted that Met QC Criteria: Aug 10, 2026
First Posted: Aug 14, 2026Actual
Last Update Submitted that Met QC Criteria: Aug 10, 2026
Last Update Posted: Aug 14, 2026Actual
Last Verified: Jul 2026

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