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In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Advanced Platelet Rich Fibrin (A-PRF) | Active Comparator | A-PRF was applied into the tooth socket after mandibular third molar surgery. |
|
| Leukocyte- and platelet-rich fibrin (L-PRF) | Active Comparator | L-PRF was applied into the tooth socket after mandibular third molar surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Advanced Platelet Rich Fibrin (A-PRF) | Genetic | blood samples collected in 10 ml of vacuumed plain glass tubes were centrifuged for 14 minutes at 1500 rpm without anticoagulant agents in order to obtain A-PRF |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Scores Evaluted | For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain). | 1st day after the operation. |
| Pain Scores Evaluted | For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain). | 2nd day after the operation. |
| Pain Scores Evaluted | For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain). | 3rd day after the operation. |
| Pain Scores Evaluted | For the postoperative period, the pain scores change was evaluated with the help of the visual analog scale (VAS) ranging from 0 (no pain) to 10 (most severe pain). | 7th day after the operation. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Analgesics Taken by the Patients | Each patient was evaluated on the 1st, 2nd, 3rd, and 7th days after the operation. | |
| Trismus | Trismus was assessed by measuring the distance between the mesioincisal corner of the maxillary and mandibular right incisors while mouth was fully opened |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mehmet G Caymaz, DDS | Near East University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Near East University | Mersin | 99138 | Turkey (Türkiye) |
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patients with bilateral impacted mandibular third molar which surgically operated at different times
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| Leukocyte- and platelet-rich fibrin (L-PRF) | Genetic | blood samples collected in 10 ml of glass coated plastic tubes were centrifuged without anticoagulant agents for 10 minutes in order to obtain L-PRF |
|
| Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation. |
| Swelling on the cheek | In order to record swelling, a modification of the tape measurement method | Each patient was evaluated in order to obtain measurements on the 1st, 2nd, 3rd, and 7th days after the operation. |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D014313 | Trismus |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013035 | Spasm |
| D020879 | Neuromuscular Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D007958 | Leukocyte Count |
| ID | Term |
|---|---|
| D001772 | Blood Cell Count |
| D002452 | Cell Count |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006403 | Hematologic Tests |
| D008919 | Investigative Techniques |
| D002468 | Cell Physiological Phenomena |
| D001790 | Blood Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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