Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

Comparison of the Effect of Advanced Platelet-rich Fibrin and Leukocyte- and Platelet-rich Fibrin on Outcomes After Removal of Impacted Mandibular Third Molar: A Randomised Split-mouth Study

In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.

Inclusion Criteria:

• age≥18
• the presence of bilaterally symmetrically impacted mandibular third molar, which requires an extraction for prophylactic reasons
• absence of systemic diseases
• absence of chronic opioid taken;
• not being pregnant
• not smoking and no alcohol usage
• the absence of allergy to penicillin or any other drugs used during standardized postoperative therapy.

Exclusion Criteria:

• tooth needed to be sectioning during the operation
• operation time exceeding 30 minutes
• the cases with severe periodontal disease or acute pericoronitis,
• the cases using antibiotics for an existing infection
• the cases not capable of following postoperative instructions