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The aim of this study was investigate the comparison of postoperative effects of low laser treatment and platelet-rich fibrin application on mandibular impacted third molar tooth extraction. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 4 randomly separated groups. In group 1, PRF was applied to the tooth socket. In group 2, PRF was applied to the tooth socket combined with Low Laser Treatment extraorally to the extraction area for three days within surgery day In group 3, Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day. In group 4 (control group), tradional osteomy was made. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. All of the 4 groups patients were prescribed an 875/125 mg amoxicillin/clavulanic acid tablet twice daily for five days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | platelet rich fibrin placed into the socket of the extraciton tooth + Augmentin 1gr tablet prescribed 2 times a day |
| |
| Group 2 | platelet rich fibrin placed in to the socket of the extractraciton tooth combined with low laser treatment extraorally to the extraction area for three days within surgery day + Augmentin 1gr tablet prescribed 2 times a day |
| |
| Group 3 | Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day + Augmentin 1gr tablet prescribed 2 times a day |
| |
| Control group. | Tradional osteomy was made. + Augmentin 1gr tablet prescribed 2 times a day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnoses | Diagnostic Test | All of the patients withstand a radiological examination, including panoramic radiography, and all were handled by the same surgeon and assistant. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 1 |
| Visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 2 |
| Visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 3 |
| Visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 7 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 1 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 2 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 3 |
| Trismus |
| Measure | Description | Time Frame |
|---|---|---|
| the number of analgesic tablets | Day 1 | |
| the number of analgesic tablets | Day 2 | |
| the number of analgesic tablets |
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Inclusion Criteria:
Exclusion Criteria:
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community aged between 18-40 without any important systemic disease.
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| Name | Affiliation | Role |
|---|---|---|
| Beste Erismen Agan | Near East University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Near East University | Nicosia | Lefkosa | 99138 | Cyprus |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16706690 | Background | Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS, Yeager RL, Millsap DS, Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Clinical and experimental applications of NIR-LED photobiomodulation. Photomed Laser Surg. 2006 Apr;24(2):121-8. doi: 10.1089/pho.2006.24.121. | |
| 20203347 |
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| traditional osteotomies | Procedure | In all groups the flap incision was triangular in shape which avoids muscle involvement (Archer flap). |
|
| platelet rich fibrin | Biological | Platelet rich fibrin (PRF), is an example and popular procedure for accelerate healing of soft and hard tissue because of the presence of various growth factors.a blood sample was taken without anticoagulant in 10 mL glass-coated plastic tubes that were immediately centrifuged (Elektro-mag M415P) at 3,000 rpm for 10 min (approximately 400 g) (13). The platelet-poor plasma that accumulated at the top of the tubes was discarded.PRF was dissected approximately 2 mm below its contact point with the red corpuscles situated beneath, to include any remaining platelets that may have localized below the junction between the PRF and red corpuscles. |
|
| Antibiotics, Penicillin | Drug | Antibiotics are prescribed for the patients. |
|
| low laser therapy, bicure laser | Device | There are studies in the literature that low-energy lasers have positive effects on the biological and biochemical processes of wound healing. Acceleration of local circulation, increase in cell proliferation and collagen synthesis are among the various effects of laser application. B Cure Dental Pro Laser application will be applied to the patient for the first 3 days. Low dose laser application will be applied to the angulus area, covering the surgical area for 8 minutes. Before this laser procedure, the patient will be asked to fill out a pain scale. This pain scale and the number of analgesics used will be monitored for 3 days. |
|
| Analgesic | Drug | Analgesics are prescribed for the patients. |
|
Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. |
| Day 7 |
| Swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 1 |
| Swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 2 |
| Swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 3 |
| Swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 7 |
| Day 3 |
| the number of analgesic tablets | Day 7 |
| Krynicka I, Rutowski R, Staniszewska-Kus J, Fugiel J, Zaleski A. The role of laser biostimulation in early post-surgery rehabilitation and its effect on wound healing. Ortop Traumatol Rehabil. 2010 Jan-Feb;12(1):67-79. |
| 34901267 | Background | Donmezer CM, Bilginaylar K. Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study. Biomed Res Int. 2021 Dec 2;2021:3040661. doi: 10.1155/2021/3040661. eCollection 2021. |
| 31589558 | Background | Feslihan E, Eroglu CN. Can Photobiomodulation Therapy Be an Alternative to Methylprednisolone in Reducing Pain, Swelling, and Trismus After Removal of Impacted Third Molars? Photobiomodul Photomed Laser Surg. 2019 Nov;37(11):700-705. doi: 10.1089/photob.2019.4696. Epub 2019 Oct 7. |
| 40134000 | Derived | Erismen Agan B, Uyanik LO, Donmezer CM. Comparison of the postoperative effect of low laser therapy and platelet rich fibrin on mandibular third molar surgery: a randomized study. BMC Oral Health. 2025 Mar 25;25(1):427. doi: 10.1186/s12903-025-05828-3. |
| ID | Term |
|---|---|
| D003933 | Diagnosis |
| D010406 | Penicillins |
| D000700 | Analgesics |
| ID | Term |
|---|---|
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013457 | Sulfur Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
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