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The aim of this study was investigate the effectiveness of Local Antibiotic Applications With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo and In Vitro. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 3 randomly separated groups. For the first and second group, Platelets Rich Fibrin+ local antibiotics were applied into the tooth socket. For the first group, amoxicillin was applied and for the second group, clindamycin was applied. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed. |
| |
| group 1 | platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth. |
| |
| group 2 | platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnosis | Diagnostic Test | All of the patients withstand a radiological examination, including panoramic radiography, and all were handled by the same surgeon and assistant. |
|
| Measure | Description | Time Frame |
|---|---|---|
| visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 1 |
| visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 2 |
| visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 3 |
| visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 7 |
| visual analogue scale (VAS) | It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured. | Day 15 |
| swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 1 |
| swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. |
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| Measure | Description | Time Frame |
|---|---|---|
| Amount of analgesic tablets | Check the patients analgesic number of days 1,2,3,7 and 15. | day 1,2,3,7 and 15 |
Inclusion Criteria:
Exclusion Criteria:
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The patients with no systemic diseases aged between 19-45
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| Name | Affiliation | Role |
|---|---|---|
| Ceren Melahat Dönmezer | Near East University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Near east University | Nicosia | Lefkosa | 99138 | Cyprus |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34901267 | Result | Donmezer CM, Bilginaylar K. Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study. Biomed Res Int. 2021 Dec 2;2021:3040661. doi: 10.1155/2021/3040661. eCollection 2021. | |
| 30975961 | Result |
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| Analgesic | Drug | Analgesics are prescribed for the patients for all groups. |
|
| traditional osteotomies | Procedure | In all groups the flap incision was triangular in shape which avoids muscle involvement (Archer flap). |
|
| Platelet Rich Fibrin | Biological | Platelet rich fibrin (PRF), is an example and popular procedure for accelerate healing of soft and hard tissue because of the presence of various growth factors.a blood sample was taken without anticoagulant in 10 mL glass-coated plastic tubes that were immediately centrifuged (Elektro-mag M415P) at 3,000 rpm for 10 min (approximately 400 g) (13). The platelet-poor plasma that accumulated at the top of the tubes was discarded.PRF was dissected approximately 2 mm below its contact point with the red corpuscles situated beneath, to include any remaining platelets that may have localized below the junction between the PRF and red corpuscles. |
|
| Antibiotic | Drug | no systemic antibiotics are prescribed for the patients for all groups. |
|
| Day 2 |
| swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 3 |
| swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 7 |
| swelling | measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible. | Day 15 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 1 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 2 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 3 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 7 |
| Trismus | Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening. | Day 15 |
| Caymaz MG, Uyanik LO. Comparison of the effect of advanced platelet-rich fibrin and leukocyte- and platelet-rich fibrin on outcomes after removal of impacted mandibular third molar: A randomized split-mouth study. Niger J Clin Pract. 2019 Apr;22(4):546-552. doi: 10.4103/njcp.njcp_473_18. |
| 30629300 | Result | Polak D, Clemer-Shamai N, Shapira L. Incorporating antibiotics into platelet-rich fibrin: A novel antibiotics slow-release biological device. J Clin Periodontol. 2019 Feb;46(2):241-247. doi: 10.1111/jcpe.13063. |
| 26209242 | Result | Uyanik LO, Bilginaylar K, Etikan I. Effects of platelet-rich fibrin and piezosurgery on impacted mandibular third molar surgery outcomes. Head Face Med. 2015 Jul 26;11:25. doi: 10.1186/s13005-015-0081-x. |
| ID | Term |
|---|---|
| D010146 | Pain |
| D013203 | Staphylococcal Infections |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D003933 | Diagnosis |
| D000700 | Analgesics |
| D000900 | Anti-Bacterial Agents |
| ID | Term |
|---|---|
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |
| D000890 | Anti-Infective Agents |
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