RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging | NCT07727369

NCT07727369

Overview

NCT ID: NCT07727369
Lead Sponsor: University Hospital, GrenobleOTHER
Official Title: RePer-AGE: Reorganization of Visuo-cognitive Functions Based on Peripheral Vision With Aging
Brief Summary: The RePer-AGE study investigates how central and peripheral vision contribute to visual recognition and how these mechanisms change with normal aging. The study is based on the hypothesis that peripheral vision provides rapid global information that supports visual recognition through predictive mechanisms. Healthy young adults (18-30 years) and older adults (60-85 years) will undergo visual psychophysical testing, ophthalmological examinations, and, for a subset of participants, functional magnetic resonance imaging (fMRI). The results are expected to improve our understanding of age-related changes in visuo-cognitive functions and provide reference data for future studies on age-related visual disorders.
Conditions: Aging
Visual Perception

Status and Timeline

Status: Not yet recruiting
Last Update Posted: Jul 27, 2026Actual
Start Date: Sep 1, 2026Estimated
Primary Completion Date: Mar 2030Estimated
Completion Date

Participation Criteria

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

Healthy young adults aged 18 to 30 years or healthy older adults aged 60 to 85 years.

Normal or corrected-to-normal visual acuity.

No ophthalmological disease affecting visual function.

For participants aged 60 years or older: Mini-Mental State Examination (MMSE) score ≥23.

Affiliated with a national health insurance system.

Written informed consent.

Non inclusion Criteria:

Individuals protected under French regulations governing research involving human participants.

Employees or individuals under the direct authority of the investigators.

History of neurological or psychiatric disorders likely to affect visual or cognitive functions.

Current treatment likely to alter visual function or vigilance.

MRI contraindications (metallic implants, pacemaker, severe claustrophobia, or other MRI safety contraindications) for participation in the MRI arm only.

Study Plan

Study Type: Interventional
Phase: Not Applicable
Enrollment: 160Estimated
Primary Purpose: Basic Science
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: None (Open Label)

Contacts and Locations

Central Contacts: Carole Peyrin, PhDContact
carole.peyrin@univ-grenoble-alpes.fr0033615351350

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