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Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Primary open-angle glaucoma (POAG) group |
| ||
| Age-matched normally sighted control group |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Psychophysical evaluation | Behavioral | All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard. |
| Measure | Description | Time Frame |
|---|---|---|
| Psychophysical measure : Percentage of correct response | Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment | Through study completion of 45 months |
| Psychophysical measure : Mean reaction time in milliseconds | Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment | Through study completion of 45 months |
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Inclusion Criteria:
For patients :
For healthy volunteers :
Exclusion Criteria:
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POAG patients and age-matched normally sighted controls
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carole Peyrin, PhD | Contact | 04 76 82 58 79 | carole.peyrin@univ-grenoble-alpes.fr |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29481572 | Background | Roux-Sibilon A, Rutge F, Aptel F, Attye A, Guyader N, Boucart M, Chiquet C, Peyrin C. Scene and human face recognition in the central vision of patients with glaucoma. PLoS One. 2018 Feb 26;13(2):e0193465. doi: 10.1371/journal.pone.0193465. eCollection 2018. | |
| 31826252 | Background | Roux-Sibilon A, Trouilloud A, Kauffmann L, Guyader N, Mermillod M, Peyrin C. Influence of peripheral vision on object categorization in central vision. J Vis. 2019 Dec 2;19(14):7. doi: 10.1167/19.14.7. |
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Anonymized individual participant data will be share in the context of publications through the Open Science Framework, a tool that promotes open, centralized workflows.
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Data will become available after publications with no limit time
Link to the Open Science Framework
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| 33571079 | Background | Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Feb 11:1-15. doi: 10.1162/jocn_a_01689. Online ahead of print. |