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The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.
This study is a single-center, double-blinded, parallel human trial designed to evaluate the skin beauty effect of oral collagen drink and MAXI collagen drink.
Healthy adult participants aged 18-60 years will be enrolled. Participants will be informed to consume test samples daily for 4 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 1 week, and 4 weeks of consumption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Collagen Drink | Active Comparator | oral intake 5 g collagen daily |
|
| MAXI Collagen Drink | Experimental | oral intake 15 mL MAXI collagen daily (equivalent to 5 g of deep hydrolyzed collagen net weight) |
|
| MAXI Collagen Drink_High dose | Experimental | oral intake 30 mL MAXI collagen daily (equivalent to 10 g of deep hydrolyzed collagen net weight) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collagen Drink | Dietary Supplement | consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 5 g Collagen Powder |
|
| Measure | Description | Time Frame |
|---|---|---|
| The change of collagen fiber fluorescence intensity | SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to evaluate the density and quality of dermal collagen fibers. | Change from Baseline collagen intensity at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin elasticity | Cutometer® MPA580 (CK, Germany) was utilized to measure the gross elasticity of the skin using suction method. | Change from Baseline skin elasticity at 4 weeks |
| The change of skin firmness |
| Measure | Description | Time Frame |
|---|---|---|
| The change of skin brightness (L*) | Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin brightness (L*). | Change from Baseline skin brightness (L*) at 4 weeks |
| The change of skin individual typology angle (ITA) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| YAO PAN | Beijing Ewish Testing Technology Co.,ltd. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Ewish Testing Technology Co.,ltd. | Beijing | China |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
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| MAXI Collagen Drink | Dietary Supplement | consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 15 mL MAXI Collagen Liquid (equivalent to 5 g of deep hydrolyzed collagen net weight) |
|
| MAXI Collagen Drink_High dose | Dietary Supplement | consume 1 bottle of the test samples daily for 4 consecutive weeks, each bottle containing 30 mL MAXI Collagen Liquid (equivalent to 10 g of deep hydrolyzed collagen net weight) |
|
Cutometer® MPA580 (CK, Germany) was utilized to measure skin firmness and the area under the suction curve.
| Change from Baseline skin firmness at 4 weeks |
| The change of epidermal thickness | SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to measure the depth of the epidermal layer using optical imaging. | Change from Baseline epidermal thickness at 4 weeks |
| The change of cheek skin roughness | AEVA-HE (EOTECH, France) was utilized to measure the arithmetic average roughness (Ra value) of the cheek surface. | Change from Baseline skin roughness at 4 weeks |
| The change of the Dermal-Epidermal Junction (DEJ) structures | SUPERVISION-780 In-Vivo Imaging System (Survface, China) was utilized to assess the structural integrity and epithelial-connective tissue interface (ECTI) of the DEJ. | Change from Baseline DEJ status at 4 weeks |
| The change of nasolabial folds volume | AEVA-HE (EOTECH, France) was utilized to quantify the 3D morphological changes of the nasolabial folds volume. | Change from Baseline wrinkle parameters at 4 weeks |
| The change of nasolabial folds depth | AEVA-HE (EOTECH, France) was utilized to quantify the 3D morphological changes of the nasolabial folds depth. | Change from Baseline wrinkle parameters at 4 weeks |
| The change of crow's feet volume | AEVA-HE (EOTECH, France) was utilized to measure the severity of crow's feet volume. | Change from Baseline crow's feet parameters at 4 weeks |
| The change of crow's feet depth | AEVA-HE (EOTECH, France) was utilized to measure the severity of crow's feet depth. | Change from Baseline crow's feet parameters at 4 weeks |
| The change of the volume of fine lines under the eyes | AEVA-HE (EOTECH, France) was utilized to assess the volume of fine lines under the eyes. | Change from Baseline fine lines at 4 weeks |
| The change of the mean depth of fine lines under the eyes | AEVA-HE (EOTECH, France) was utilized to assess the mean depth of fine lines under the eyes. | Change from Baseline fine lines at 4 weeks |
| The change of cheek (malar) volume | AEVA-HE (EOTECH, France) was utilized to measure the 3D volume of the cheek area for lifting effects. | Change from Baseline cheek volume at 4 weeks |
| The change of jawline length | AEVA-HE (EOTECH, France) was utilized to measure the linear length and contour of the jawline. | Change from Baseline jawline parameters at 4 weeks |
| The change of skin pores counts | AEVA-HE (EOTECH, France) was utilized to perform 3D imaging and quantification of skin pores counts. | Change from Baseline pore parameters at 4 weeks |
| The change of skin pores volume | AEVA-HE (EOTECH, France) was utilized to perform 3D imaging and quantification of skin pores volume. | Change from Baseline pore parameters at 4 weeks |
| The change of skin hydration | Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydration. Units: arbitrary Corneometer® units 0-120. | Change from Baseline skin hydration at 4 weeks |
| The change of transepidermal water loss (TEWL) | Tewameter® TM300 (CK, Germany) was utilized to measure the evaporation rate of water from the skin. Units: g/h/m^2. | Change from Baseline TEWL at 4 weeks |
Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin individual typology angle (ITA).
| Change from Baseline skin ITA at 4 weeks |
| The change of skin color parameters | Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin redness (a*). | Change from Baseline skin redness (a*) at 4 weeks |
| The change of skin color parameters | Skin-Colorimeter CL400 (CK, Germany) was utilized to measure skin yellow tone (b*). | Change from Baseline skin yellow tone (b*) at 4 weeks |