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This study will evaluate the clinical efficacy of injectable alloplastic bone grafts in terms of radiography and histology in order to preserve tooth sockets following extraction. Methodology: Twenty new extraction sockets from twenty surgically extracted non-restorable mandibular molar teeth will be used in this clinical investigation.
Using computer randomization (http://www.randomlists.com), the 20 extraction sockets will be split into two equal groups (n=10) at random. Ten sockets (the experimental group) will undergo socket preservation using injectable bone substitute biomaterial. To permit normal physiological healing, the remaining 10 sockets (control group) will left unfilled. Clinical examination will be carried out after 2 days, 1 week, 2 weeks, 1 month, and 4 months, while after 4 months, radiographic measurements of bone dimension changes were carried out, and the histological inspection will be carried out three months after the removal of the tooth.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the experimental group (IBS group) | Experimental | Ten extraction sockets will undergo socket preservation using injectable bone substitute biomaterial following atraumatic tooth extraction and socket curettage. |
|
| control group (natural healing) | Active Comparator | Ten extraction sockets will be left unfilled after atraumatic extraction to allow normal physiological healing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Injectable Alloplastic Bone | Procedure | Ten extraction sockets will undergo socket preservation using injectable bone substitute biomaterial following atraumatic tooth extraction and socket curettage. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in buccolingual ridge width assessed by CBCT | Buccolingual ridge width will be measured radiographically using CBCT immediately post-extraction (baseline) and after 4 months | Baseline and 4 months |
| Bone density assessed by CBCT | Bone density of the extraction socket will be evaluated radiographically using CBCT gray values immediately post-extraction (baseline) and after 4 months. | Baseline and 4 months |
| Percentage of newly formed bone assessed histomorphometrically | The percentage of newly formed bone will be evaluated histomorphometrically using hematoxylin and eosin staining during implant placement. | 3 months |
| Percentage of residual graft material | Residual graft material percentage will be assessed histomorphometrically using hematoxylin and eosin staining during implant placement. | 3 months |
| Percentage of connective tissue | Connective tissue percentage will be assessed histomorphometrically using hematoxylin and eosin staining during implant placement. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Mucosal healing | Clinical mucosal healing will be assessed by the presence or absence of infection, swelling, and adverse tissue reaction during follow-up visits. | Up to 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Moataz Selmi | Contact | 01006848382 | moatazselmi93@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| dr mohamed elsholkamy el sholkamy, Professor | Suez Canal University | Study Director |
| moataz mohsen zaki, master | Suez Canal University | Principal Investigator |
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| natural healing (no graft) | Procedure | Ten extraction sockets will be left unfilled after atraumatic extraction to allow normal physiological healing. |
|
| Dr merihan nabih elmansy |
| Suez Canal University |
| Study Director |
| dr ahmed abdelmohsen younis | Suez Canal University | Study Director |