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| Name | Class |
|---|---|
| University Hospital Ostrava | OTHER |
| Private dental practice Jalůvka | UNKNOWN |
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Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.
The study evaluates four different approaches to alveolar ridge preservation after tooth extraction. Eligible patients aged 18-70 years will undergo minimally traumatic extraction. Four treatment modalities will be compared: 1) Spontaneous healing secured with a stitch (control group), 2) Application of collagen sponge (Parasorb Cone, Resorba, Germany) secured with a stitch, 3) Application of a tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic) covered with a collagen sponge (Parasorb Cone) and secured with a stitch. 4) Application of autogenous dentin, covered with a collagen sponge (Parasorb Cone) and secured with a stitch. Alveolar ridge dimensions will be measured on CBCT before extraction and again after six months. Primary outcomes include the absolute and relative change in ridge width and height at 1 mm, 3 mm, and 5 mm below the highest point of the alveolar bone as per Del Canto-DÃaz, 2019. Patient factors (periodontal biotype, soft tissue phenotype, and vestibular thickness of the alveolar bone) will be recorded to allow subgroup analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spontaneous healing secured with a stitch (control group) | Active Comparator | Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material. |
|
| Colagen sponge | Experimental | Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch. |
|
| Tricalcium phosphate xenograft | Experimental | Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch. |
|
| Autogenous dentin | Experimental | Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tooth extraction left to heal spontaneously | Procedure | Wound after the tooth extraction will be secured with a stitch without addition of any augmentation material. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Alveolar bone width | Absolute and relative change in the alveolar bone width at 1 mm, 3 mm, and 5 mm below the alveolar crest measured from CBCT imagery. | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Petr Jalůvka, MDDr. | Contact | +420 596 623 518 | petr.jaluvka@osu.cz |
| Name | Affiliation | Role |
|---|---|---|
| Martin Starosta, Assoc. Prof. | University of Ostrava | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Ostrava | Recruiting | Ostrava | 70852 | Czechia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33405453 | Background | Yuceer-Cetiner E, Ozkan N, Onger ME. Effect of Autogenous Dentin Graft on New Bone Formation. J Craniofac Surg. 2021 Jun 1;32(4):1354-1360. doi: 10.1097/SCS.0000000000007403. | |
| 39044178 | Background | Lopez Sacristan H, Del Canto Pingarron M, Alobera Gracia MA, de Elio Oliveros J, Diaz Pedrero R, Seco-Calvo J. Use of autologous tooth-derived material as a graft in the post-extraction socket. Split-mouth study with radiological and histological analysis. BMC Oral Health. 2024 Jul 23;24(1):832. doi: 10.1186/s12903-024-04576-0. |
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| ID | Term |
|---|---|
| D014081 | Tooth Extraction |
| C018392 | tricalcium phosphate |
| ID | Term |
|---|---|
| D019647 | Oral Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D003813 | Dentistry |
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| Tooth extraction plus collagen sponge | Procedure | Wound after the tooth extraction will be filled with a collagen sponge (Parasorb Cone, Resorba, Germany) and secured with a stitch. |
|
| Tooth extraction plus tricalcium phosphate | Procedure | Wound after the tooth extraction will be filled with tricalcium phosphate xenograft (Poresorb TCP, Lasak, Czech Republic), covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch. |
|
| Tooth extraction plus autogenous dentin | Procedure | Wound after the tooth extraction will be filled with grounded autogenous dentin, covered with a collagen sponge (Parasorb Cone, Resorba, Germany), and secured with a stitch. |
|
| 35830314 | Background | Isola G, Santonocito S, Di Tommasi S, Torrisi S, Iorio-Siciliano V, Caltabiano R, Ramaglia L, Torrisi P. Use of Autogenous Tooth-Derived Mineralized Dentin Matrix in the Alveolar Ridge Preservation Technique: Clinical and Histologic Evaluation. Int J Periodontics Restorative Dent. 2022 Jul-Aug;42(4):497-504. doi: 10.11607/prd.6170. |
| 37455372 | Background | Yang F, Ruan Y, Bai X, Li Q, Tang X, Chen J, Chen Y, Wang L. Alveolar ridge preservation in sockets with severe periodontal destruction using autogenous partially demineralized dentin matrix: A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Dec;25(6):1019-1032. doi: 10.1111/cid.13247. Epub 2023 Jul 16. |
| 38179035 | Background | Hussain AA, Al-Quisi AF, Abdulkareem AA. Efficacy of Autogenous Dentin Biomaterial on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial. Biomed Res Int. 2023 Dec 27;2023:7932432. doi: 10.1155/2023/7932432. eCollection 2023. |
| 30573707 | Background | Del Canto-Diaz A, de Elio-Oliveros J, Del Canto-Diaz M, Alobera-Gracia MA, Del Canto-Pingarron M, Martinez-Gonzalez JM. Use of autologous tooth-derived graft material in the post-extraction dental socket. Pilot study. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24(1):e53-e60. doi: 10.4317/medoral.22536. |