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| ID | Type | Description | Link |
|---|---|---|---|
| 4309/B3/DT.03.08/2025 | Other Grant/Funding Number | Direktorat Kelembagaan, Direktorat Jenderal Pendidikan Tinggi, Sains, dan Teknologi, Republik Indonesia |
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This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.
This study used a controlled pretest-posttest, four-arm interventional design to examine the effects of short-term creatine monohydrate supplementation on cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were allocated into four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise. The intervention lasted 7 days.
Participants in the exercise groups completed a bodyweight HIIT protocol consisting of two rounds. Round 1 used 40 seconds of work and 20 seconds of rest, and round 2 used 30 seconds of work and 15 seconds of rest, with 30 seconds of rest between rounds. The session included 14 sequential movements and was preceded by a 5-minute warm-up and followed by a 5-minute cool-down.
Cognitive performance was assessed before and after the intervention using visual reaction time (VRT), go/no-go visual reaction time (GNGVRT), and Trail Making Test Parts A and B. These measures were selected to capture processing speed, inhibitory control, attention, and executive function. The study was approved by the ethics committee of Universitas Negeri Malang, and written informed consent was obtained from all participants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo + Exercise | Placebo Comparator | Participants received placebo supplementation using maltodextrin for 7 days and performed high-intensity interval training. |
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| Placebo Without Exercise | Placebo Comparator | Participants received placebo supplementation using maltodextrin for 7 days without exercise intervention. |
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| Creatine 0,1 g/KgBW/day + Exercise | Experimental | Participants received creatine monohydrate supplementation at 0,1 g/KgBW/day for 7 days and performed high-intensity interval training. |
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| Creatine 0,3 g/KgBW/day + Exercise | Experimental | Participants received creatine monohydrate supplementation at 0,3 g/KgBW/day for 7 days and performed high-intensity interval training. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Creatine Monohydrate | Drug | Creatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days. |
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| Measure | Description | Time Frame |
|---|---|---|
| Go/No-Go Visual Reaction Time False Alarm Errors | Number of false alarm (commission) errors recorded during the Go/No-Go Visual Reaction Time test. Lower values indicate better inhibitory control. | Baseline and Day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| Go/No-Go Visual Reaction Time | Average response time for correct go trials during the Go/No-Go Visual Reaction Time test, expressed in milliseconds. Lower values indicate faster processing speed. | Baseline and Day 7 |
| Trail Making Test Part B Completion Time |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratory Sports Science Universitas Negeri Malang | Malang | East Java | 65145 | Indonesia |
The plan for sharing individual participant data has not yet been finalized.
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Participants were assigned to one of four parallel groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise.
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| Creatine Monohydrate | Drug | Creatine monohydrate supplementation at a dose of 0,3 g/KgBW/day for 7 days. |
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| Placebo | Drug | Placebo supplementation for 7 days |
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| High Intensity Interval Training | Behavioral | A bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds. |
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Trail Making Test Part B Completion Time |
| Baseline and Day 7 |
| Visual Reaction Time | Simple visual reaction time measured in milliseconds. Lower values indicate faster processing speed. | Baseline and Day 7 |
| Trail Making Test Part A Completion Time | Trail Making Test Part A Completion Time | Baseline and Day 7 |
| ID | Term |
|---|---|
| D003401 | Creatine |
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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