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Resistance training as well as creatine supplementation may be beneficial for cognitive function, such as memory and attention. Therefore, the investigators speculate that resistance training combined with creatine supplementation would promote additive benefits on cognitive function in elderly women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo control | Placebo Comparator | this only receives placebo (dextrose) |
|
| placebo and exercise | Experimental | this is trained and receives placebo |
|
| creatine supplementation | Experimental | this is non-exercise trained and receives creatine supplementation |
|
| Creatine and Exercise | Experimental | this is exercised trained and receives creatine supplementation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| creatine supplementation | Dietary Supplement | 20g/d for 7 days followed by 5g/d for 23 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| cognitive function | six months |
| Measure | Description | Time Frame |
|---|---|---|
| physical capacity | muscle strength and function | six months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bruno Gualano, PhD | University of Sao Paulo | Principal Investigator |
| Antonio H Lancha Junior, PhD | University of Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Medicine - Division of Rheumatology | São Paulo | São Paulo | 05508-030 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24098469 | Derived | Alves CR, Merege Filho CA, Benatti FB, Brucki S, Pereira RM, de Sa Pinto AL, Lima FR, Roschel H, Gualano B. Creatine supplementation associated or not with strength training upon emotional and cognitive measures in older women: a randomized double-blind study. PLoS One. 2013 Oct 3;8(10):e76301. doi: 10.1371/journal.pone.0076301. eCollection 2013. |
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| ID | Term |
|---|---|
| D003401 | Creatine |
| D005947 | Glucose |
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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| Placebo (Dextrose) | Other | 20g/d for 7 days followed by 5g/d for 23 weeks |
|
| Resistance training | Other | resistance training twice a week for 24 weeks |
|
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |