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Resistance training as well as creatine supplementation may increase bone mass. Therefore, the investigators speculate that resistance training combined with creatine supplementation would promote additive benefits on bone mass in elderly women with osteopenia and osteoporosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control and exercise | Placebo Comparator | this is trained and receives placebo |
|
| creatine | Experimental | this is non-exercise trained and receives creatine supplementation |
|
| exercise and creatine | Experimental | this is exercised trained and receives creatine supplementation |
|
| placebo | Placebo Comparator | this only receives placebo (dextrose) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| creatine supplementation | Dietary Supplement | 20g/d for 7 days followed by 5g/d for 23 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| bone mineral density | six months |
| Measure | Description | Time Frame |
|---|---|---|
| cognition | six months | |
| physical capacity | including muscle strength, balance and muscle function | six months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rosa MR Pereira, PhD | University of Sao Paulo | Principal Investigator |
| Bruno Gualano, PhD | University of Sao Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Medicine - Division of Rheumatology | São Paulo | São Paulo | 01246-903 | Brazil |
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| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D003401 | Creatine |
| D015444 | Exercise |
| D005947 | Glucose |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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| exercise training | Other | resistance training twice a week for 24 weeks |
|
| placebo (dextrose) | Other | 20g/d for 7 days followed by 5g/d for 23 weeks |
|
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |