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The aim of the current project is to investigate the impact of 3mg of oral estradiol valerate on the formation of intrusive memories after analog trauma.
A well-established stress-film paradigm will be used to induce intrusive symptoms in healthy participants. In a double-blind placebo-controlled study, the impact of oral estradiol on intrusive symptoms during and immediately after exposure to a trauma film will be examined. The primary hypothesis is that exogenous oral estradiol will decrease the number of intrusive memories recorded in the four days following experimental trauma compared with placebo controls.
This project will contribute to the current understanding of intrusive memory formation in PTSD and may guide the development of future pharmacological preventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Estradiol before the trauma paradigme | Experimental | 3mg of oral estradiol valerate administered two hours before the trauma film (during acquisition of trauma associated memories) |
|
| Estradiol after the trauma paradigme | Experimental | 3mg of oral estradiol valerate administered immediately after the trauma film (during consolidation of trauma associated memories) |
|
| Placebo before and after the trauma film paradigm | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Estradiol Valerate | Drug | 3mg of Estradiol Valerate pills, administred orally |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Intrusive Memories in the following four days after the intervention | Influence of estradiol on the development of intrusive memories measured with an intrusion diary | four consecutive days |
| Measure | Description | Time Frame |
|---|---|---|
| Noradrenergic System (measured with salivary alpha-amylase - u/ml) | Influence of noradrenergic system measured with salivary alpha-amylase on the development of intrusive memories | Day 1 |
| Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L) |
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Inclusion Criteria:
Exclusion Criteria:
Female participants who identify as women
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tolou Maslahati, M.Sc. | Contact | 0049 30 450 517 567 | tolou.maslahati@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Katja Wingenfeld, Prof. Dr. | Charite University, Berlin, Germany | Principal Investigator |
| Stefan Roepke, Prof. Dr. | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité - Universitätsmedizin Berlin | Recruiting | Berlin | State of Berlin | 12203 | Germany |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| D014947 | Wounds and Injuries |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D004958 | Estradiol |
| ID | Term |
|---|---|
| D004963 | Estrenes |
| D004962 | Estranes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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Double Blind, randomized, placebo controlled
| Placebo | Drug | Plabo pill |
|
Influence of HPA-axis measured with salivary cortisol on the development of intrusive memories |
| Day 1 |
| Estradiol and Progesterone | Influence of salivary endogenous estradiol and progesterone on the development of intrusive memories. | Day 1 |
| heart rate variability | Influence of heart rate variability on the development of intrusive memories | Day 1 |
| D011083 |
| Polycyclic Compounds |
| D045166 | Estradiol Congeners |
| D012739 | Gonadal Steroid Hormones |
| D042341 | Gonadal Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |