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| Name | Class |
|---|---|
| Central Institute of Mental Health, Mannheim | OTHER |
The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin and trauma film paradigm | Experimental |
| |
| Placebo and trauma film paradigm | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin nasal spray | Drug |
| ||
| Placebos |
| Measure | Description | Time Frame |
|---|---|---|
| Intrusive memories | Influence of oxytocin on the development of intrusive memories measured with an intrusion diary | four consecutive days |
| Measure | Description | Time Frame |
|---|---|---|
| Noradrenergic System (measured with salivary alpha-amylase - u/ml) | Influence of oxytocin on the noradrenergic system measured with salivary alpha-amylase | Day 1 |
| Genetic polymorphism | Influence of genetic polymorphism of the oxytocin receptor on intrusive memories measured with an intrusion diary |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Roepke, PD Dr. | Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin | Berlin | 12203 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34887528 | Derived | Schultebraucks K, Maslahati T, Wingenfeld K, Hellmann-Regen J, Kraft J, Kownatzki M, Behnia B, Ripke S, Otte C, Roepke S. Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women. Neuropsychopharmacology. 2022 Apr;47(5):1046-1054. doi: 10.1038/s41386-021-01247-4. Epub 2021 Dec 9. |
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Placebo nasal spray |
|
| four consecutive days |
| Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L) | Influence of oxytocin on the HPA-axis measured with salivary cortisol | Day 1 |