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The purpose of the study is to examine whether oxytocin and certain polygenic risk scores affect the development of intrusive memories, a cardinal symptom of PTSD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxytocin and trauma film paradigm | Experimental | Intervention: Drug: Oxytocin nasal spray |
|
| Placebo and trauma film paradigm | Placebo Comparator | Intervention: Drug: Placebos |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | Drug: Oxytocin nasal spray |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Intrusive Memories in the following four days after the intervention | Influence of oxytocin on the development of intrusive memories measured with an intrusion diary | four consecutive days |
| Measure | Description | Time Frame |
|---|---|---|
| Noradrenergic System (measured with salivary alpha-amylase - u/ml) | Influence of oxytocin on the noradrenergic system measured with salivary alpha-amylase | Day 1 |
| Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Roepke, Prof | Charité | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité- Universitätsmedizin Berlin | Berlin | 10249 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36739422 | Derived | Maslahati T, Wingenfeld K, Hellmann-Regen J, Kraft J, Lyu J, Keinert M, Voss A, Cho AB, Ripke S, Otte C, Schultebraucks K, Roepke S. Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women. Transl Psychiatry. 2023 Feb 4;13(1):42. doi: 10.1038/s41398-023-02339-z. |
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| ID | Term |
|---|---|
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Placebo |
| Drug |
Drug: Placebo nasal spray |
|
Influence of oxytocin on the HPA-axis measured with salivary cortisol
| Day 1 |
| Polygenic Risk Score | Influence of polygenic risk score on development of intrusive memories | four consecutive days |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |