Acute Effects of Estradiol Administration on Brain Function During Fear Learning | NCT07737613

NCT07737613

Overview

NCT ID: NCT07737613
Lead Sponsor: University of ArizonaOTHER
Official Title: Neuroimaging Study of Fear Learning: Effects of Estrogen
Brief Summary: The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones. This research will focus specifically on postmenopausal female adults, because age-related changes in cognition and declining estrogen levels may contribute to anxiety symptoms and PTSD risk later in life.
Conditions: PTSD and Trauma-related Symptoms
Cognitive Decline in Older Adults
Post Menopausal Women
Interventions

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers?: Yes
Eligibility Criteria: Inclusion Criteria:

post-menopausal

normal or corrected-to-normal vision

English speaking

stable medication use (no changes in the past three months)

Exclusion Criteria:

use of hormone therapy containing synthetic estrogen

MRI contraindications (e.g., irremovable ferrous metal in body, claustrophobia)

history of neurological disorder (including mild cognitive impairment) or moderate to severe traumatic brain injury

use of antipsychotic, opiate, or mood stabilizer (i.e., lithium) medication

history of blood clots/deep vein thrombosis, prior stroke or TIA, uncontrolled hypertension

history of migraine with aura

severe liver disease

history of breast, endometrial, or ovarian cancer

smoking >10 cigarettes/day