Sex Differences in E-Cigarette Perception

Sex Differences in E-Cigarette Perception: Study 2

This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

The goal of this protocol is to investigate how sex differences in response to menthol and nicotine influence product preference and choice. In this proposal, participants will be exposed to menthol non-nicotine and nicotine containing e-cigarettes and product preference and choice will be examined in a paradigm where a menthol nicotine-containing e-cigarette is progressively more difficult to earn, and a menthol non-nicotine e-cigarette is available at a low, fixed cost. Additionally, it will be investigated how menthol e-cigarettes with and without nicotine impact reward, appeal, and sensory effects in an initial sampling session (secondary and exploratory outcomes).

Inclusion Criteria:

• Able to read/write in English
• Current cigarette smoking
• Prior e-cigarette exposure
• Biochemically verified cigarette use
• Not trying to quit tobacco use

Exclusion Criteria:

• Significant medical concerns that would increase study risk
• Use of psychoactive drugs unless prescribed and stable
• Allergy to menthol or other e-liquid ingredients
• Dislike of menthol
• Pregnant, trying to get pregnant, breastfeeding