Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2

This study is to examine if inhaled doses of an e-cigarette flavor, alone and in combination with menthol, changes the appeal of e-cigarettes containing low and high doses of nicotine. The hypothesis is that menthol and the other experimental flavor will interact with nicotine dose to improve taste and liking for e-cigarettes.

Inclusion Criteria:

• Ages 18-20 years
• Able to read and write
• Urine cotinine levels of >250 ng/ml at screening appointment
• Use of e-cigarettes in the past month
• May or may not currently smoke traditional cigarettes

Exclusion Criteria:

• Seeking smoking cessation treatment
• Current/lifetime criteria for dependence on another psychoactive substance -Daily use of alcohol or marijuana or use of any other drugs including cocaine, opiates, stimulants
• Regular use of psychoactive drugs including anxiolytics, antidepressants and other psychostimulants
• Current or past history of psychosis or other psychiatric diagnosis such as major depression
• Any significant current medical condition