Coffee Intake Biomarker Validation and Association With Respiratory Diseases

Coffee Intake Biomarker Validation and Association With Respiratory Diseases

This proposed project aims to identify and validate biomarkers of coffee exposure in the Singapore population, and assess the association between coffee consumption (via biomarker measurements) and risk of respiratory diseases in a prospective multi-ethnic cohort in Singapore.

Specific Aim 1: To identify and quantify urinary/serum metabolite changes that are associated with coffee consumption in a dose-response intervention study.

Inclusion Criteria:

• Regular coffee drinkers aged 21-64 years old, Chinese ethnicity

Exclusion Criteria:

• Healthy individuals who are regular coffee and/or tea drinkers, aged 21-64 years old of Chinese ethnicity with no severe medical conditions and are physically-abled, can participate in the research. However, you cannot participate in or will be released from this study if the following conditions or situations apply to you:

  • Ineligible screening survey which will consist of basic demographic information and questions pertaining to inclusion/exclusion criteria such as age, gender, current medications, chronic illness, etc
  • Dislike drinking coffee and tea
  • Pregnant or breastfeeding
  • Certain medications including Zanaflex, Sirasalud, Ketanest S, Spravato and Ephedrine Sulfate (See full list of medication)
  • Present medical conditions: cancer, cardiometabolic diseases, endocrine diseases, depression, anxiety, caffeine/lactose intolerant, fear of needles and/or blood disorders
  • Recent history of major surgical operations
  • Past or current user of oral/systemic hormone treatment or therapies
  • Taken antibiotics in the last 3 months
  • Taking nutritional supplements (that contains coffee/tea-related compounds naturally found in other plants)
  • Not willing to travel to the University for the study
  • Unable to commit to completing all the sessions in the 10-week intervention study