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| Name | Class |
|---|---|
| Paulig Group | UNKNOWN |
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The aim of this project is to evaluate metabolite profile after consumption of three types of coffee differing in type of bean, degree of roasting and preparation method. Metabolite profiles will be evaluated after a) a single dose b) 3-day consumption. The study will be carried out as a three-way cross-over design with three different types of coffee. Wash-out periods where participants consume their habitual diet are implemented between all intervention periods. The first day of intervention (single dose) includes postprandial measurements during 13 hours.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coffee A | Experimental | Coffee type A. All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method. |
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| Coffee B | Experimental | Coffee type B. All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method. |
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| Coffee C | Experimental | Coffe type C. All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diet | Other | All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method. |
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| Measure | Description | Time Frame |
|---|---|---|
| Plasma concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Difference in the plasma concentrations between the different types of coffee comparing before (baseline) and after single dose intervention. | 24 hours |
| Plasma concentration-time profile over 24 hours (AUC) of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Difference in plasma AUC between the different types of coffee for each biomarker candidate. | 24 hours |
| Urine concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Difference in the urine concentrations between the different types of coffee comparing before (baseline) and after single dose intervention. | 24 hours |
| Plasma kinetic profiles of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Cmax will be estimated. | 24 hours |
| Plasma kinetic profiles of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Tmax will be estimated. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Difference in the plasma concentrations between the different types of coffee comparing before (baseline) and after single dose and three days intervention. | 4 days |
| Urine concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rikard Landberg, Dr | Chalmers University of Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Gothenburg, Department of Food and Nutrition and Sport Science | Gothenburg | Sweden |
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| ID | Term |
|---|---|
| D004032 | Diet |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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Difference in the urine concentrations between the different types of coffee comparing before (baseline) and after single dose and three days intervention. |
| 4 days |
| Plasma metabolites | Untargeted metabolomics will be performed using established methods for plasma. Analyzed exploratorily using untargeted metabolomics to find potential biomarker panels that reflect coffee consumption. Baseline compared with after intervention products. | 4 days |
| Urine metabolites | Untargeted metabolomics will be performed using established methods for urine. Analyzed exploratorily using untargeted metabolomics to find potential biomarker panels that reflect coffee consumption. Baseline compared with after intervention products. | 24 hours |
| Gut microbiome | Fecal samples will analyzed for composition of the gut microbiome, baseline compared with after 4 days of intervention products. | 4 days |
| Blood concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes. | Evaluate new simple sampling techniques using dried blood spots. | 13 hours |