Coffee Polyphenols Antioxidants

Coffee Antioxidant Efficacy in Humans

Coffee is one of the most widely consumed beverages. It contains polyphenols (chlorogenic acids) and bioavailability of these bioactive compounds is now somewhat well understood. In addition, chlorogenic acids are known to be antioxidants in the cup, but reliable evidence remains to be observed in vivo. The objective of this trial is to understand if regular (10d) coffee intake may be beneficial on biomarkers of oxidative damage measured in urine and plasma. A secondary objective is to understand if polyphenols isolated from coffee may be as beneficial as the whole beverage in reducing oxidative stress compared to placebo

This is an interventional study with a crossover randomized placebo-controlled double-blind design to assess the effect of regular consumption of coffee on oxidative stress compared to placebo.

Inclusion Criteria:

• 20 - 70 years, male and female
• healthy
• BMI 19 - 29 kg/m2
• Coffee drinkers with an average consumption of 1-3 cups per day
• having given informed consent

Exclusion Criteria:

• Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer- Have had a gastrointestinal surgery, except appendicectomy
• Difficulty to swallow
• Have a regular consumption of medication
• Have taken antibiotic therapy within the last 6 months
• Alcohol consumption > 2 units a day
• Smokers (more than 5 cigarettes per day)
• Have given blood within the last 3 weeks
• Volunteers who cannot be expected to comply with treatment
• Currently participating or having participated in another clinical trial during the last 3 weeks