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Coffee and green tea are 2 widely consumed beverages. Both contain polyphenol antioxidant compounds (chlorogenic acids for coffee and catechins for tea). The bioavailability of catechins is somewhat known and has been referenced in the literature. However, bioavailability data from tea infusion is non-existent, even though it reflects better how consumers drink this beverage. In addition, bioavailability of coffee chlorogenic acids is less understood and no dose response study has been reported so far in the literature. Thus, there is a great need to understand and reinforce our knowledge on the bioavailability of coffee and tea polyphenol compounds.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High dose coffee | Experimental | High dose of polyphenols from soluble coffee |
|
| Medium dose coffee | Experimental | Medium dose of polyphenols from soluble coffee |
|
| Low dose coffee | Experimental | Low dose of polyphenols from soluble coffee |
|
| High dose green tea | Experimental | High dose of green tea polyphenols from infusion |
|
| Medium dose green tea infusion | Experimental | Medium dose of green polyphenols from infusion |
|
| Low dose green tea infusion | Experimental | low dose of polyphenols from an infusion of green tea |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Green tea | Other | Infusion (tea bags) from commercially available green tea |
|
| Measure | Description | Time Frame |
|---|---|---|
| Compare plasma Area under the curve (AUC) of highest and lowest dose of coffee for chlorogenic and phenolic acid metabolites | Measurements done over 24h after ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| Compare Area under the curve (AUC), Maximum plasma concentration (Cmax), Time to reach maximum plasma concentration (Tmax) and half-life (T1/2) of all three doses of coffee for chlorogenic and phenolic acid metabolites | Measurements done over 12h after ingestion | |
| Compare AUC, Cmax, Tmax and T1/2 of all three doses of green tea for catechin metabolites |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maurice Beaumont, M.D., Ph.D. | Nestec | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nestle Research Center | Lausanne | 1000 | Switzerland |
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| ID | Term |
|---|---|
| D013662 | Tea |
| D003069 | Coffee |
| ID | Term |
|---|---|
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
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| Coffee | Other | Soluble coffee commercially available |
|
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| Measurements done over 12h after ingestion |
| D000066888 |
| Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |