Comparison of Fractionated Versus Bolus Administration of Different Doses of Hyperbaric Bupivacaine Combined With Opioids in Spinal Anesthesia for Caesarean Section

Comparison of Fractionated Versus Bolus Administration of Different Doses of Hyperbaric Bupivacaine Combined With Opioids in Spinal Anesthesia for Caesarean Section - A Prospective, Randomized, Single Blind Clinical Trial

This study aimed to compare the effectiveness and safety of fractionated versus bolus administration of different doses of hyperbaric bupivacaine (0.06 and 0.07 mg/cm height) combined with opioids in spinal anesthesia for cesarean section, with detailed evaluation of maternal hemodynamic effects, block characteristics and side effects.

Inclusion Criteria:

• singleton full-term pregnancy scheduled for cesarean section under spinal anesthesia
• ASA physical status II-III
• age 18-50 years
• height from 140 to 180 cm
• body weight from 40 to 130 kg

Exclusion Criteria:

• patient refusal
• contraindications to spinal anesthesia
• allergy to amide-type local anesthetics