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To assess hemodynamic changes with hyperbaric bupivacaine with spinal anesthesia
Assesment of hemodynamic changes like heart rate and blood pressure with hyperbaric bupivacaine in spinal anesthesia when given in fractionanted versus bolus dose manner
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group B (Bolus) | Active Comparator | Group B patients will be given a bolus dose of hyperbaric bupivacaine in a bolus fashion mean all of calculated drug will be given in one shot |
|
| Group F (Fractionated) | Active Comparator | In group F Spinal Anesthesia will be given as 2/3 of the initial dose will be give and then after 90 seconds remaining 1/3 dose will be given of hyperbaric bupivacaine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spinal Anesthesia (bupivacaine) | Drug | In this group B spinal Anesthesia will be given in one single shot |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean Arterial Pressure | Difference in mean arterial pressure between Group B and Group F | Baseline and up to 120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Hypotension and bradycardia | Incidence of hypotension and bradycardia after spinal Anesthesia between Group B and Group F | Baseline and up to 120 minutes |
| Requirement of vasopressors | Requirements of vasopressors if mean arterial pressure falls below 60mmHg during the procedure and up to 120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Usama, MBBS | Contact | +923008978791 | bhurgriusama@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Liaquat National Hospital | Karachi | Sindh | 74000 | Pakistan |
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| ID | Term |
|---|---|
| D000775 | Anesthesia, Spinal |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000765 | Anesthesia, Conduction |
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
| D000813 | Anilides |
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| Spinal Anesthesia (bupivacaine) | Drug | In this intervention spinal Anesthesia of bupivacaine will be given in a fractionated manner that is 2/3 of dose initially and then 1/3 after 90 seconds |
|
| Baseline and up to 120 minutes |
| D000577 |
| Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |