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Participant's baby was born prematurely and had underdeveloped lungs at birth. Most premature infants require mechanical ventilation after birth, which increases the risk of lung injury and may lead to varying degrees of bronchopulmonary dysplasia (BPD). Investigators believe that introducing an air purifier into your home environment after Participant's baby is discharged could help improve their lung development.
This study aims to non-invasively measure baby's transcutaneous carbon dioxide (PtcCO₂) levels and blood oxygen saturation (SpO₂) at home, both with and without the use of an air purifier. In addition, investigators will collect data from Kaohsiung Medical University Hospital medical records regarding the number of visits, respiratory status, height, weight, head circumference, and developmental progress. Health questionnaires will also be administered to assess changes in health outcomes and provide recommendations on improving indoor air quality in Participant's home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Comparison of Air Purifier Intervention and Frequency of Medical Visits | Experimental | Study Arm: Experimental (Air Purifier On) vs. No Intervention (Air Purifier Off） |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| air purifier | Device | air purifier with mechanism of PCO plus three in one filters (Pre-filter/High-Efficiency Activated Carbon/High-Efficiency Particulate Air (HEPA) ) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in particulate matter concentrations (PM₁, PM₂.₅, PM₄, PM₁₀, TSP) | Indoor concentrations of PM₁, PM₂.₅, PM₄, PM₁₀, and total suspended particles (TSP) will be measured before and after the use of an air purifier. Unit of Measure:µg/m³ | Baseline and up to 3 weeks after intervention |
| Change in gaseous pollutant concentrations (CH₂O, NO₂, CO, SO₂, VOC, CO₂) | Indoor gaseous pollutants, including formaldehyde (CH₂O), nitrogen dioxide (NO₂), carbon monoxide (CO), sulfur dioxide (SO₂), volatile organic compounds (VOC), and carbon dioxide (CO₂), will be measured before and after the intervention. Unit of Measure: ppm | Baseline and up to 3 weeks after intervention |
| Change in microbial concentrations (bacteria, fungi, Gram-positive, Gram-negative) | Airborne microbial concentrations, including total bacteria, total fungi, Gram-positive bacteria, and Gram-negative bacteria, will be assessed before and after the use of an air purifier. Unit of Measure: CFU/m³ | Baseline and up to 3 weeks after intervention |
| Change in lung function parameters (SVC, FVC, FEV₁,） | Change in lung volumes including Slow Vital Capacity (SVC), Forced Vital Capacity (FVC), and Forced Expiratory Volume in 1 second (FEV₁) of household members living with preterm infants. Measurements will be taken before and after the intervention. Unit of Measure: Liters (L) | Baseline and up to 3 weeks after intervention |
| Change in Airflow Rates(MMEF,FEF25,FEF50,FEF75,PEF) | Change in airflow parameters including Maximum Mid-Expiratory Flow (MMEF), Forced Expiratory Flow at 25% (FEF₂₅), 50% (FEF₅₀), and 75% (FEF₇₅) of FVC, and Peak Expiratory Flow (PEF) of household members living with preterm infants. Measurements will be taken before and after the intervention. Unit of Measure: Liters per second (L/s) |
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Inclusion Criteria:Children aged 0 to 6 years who were born at less than 37 weeks of gestation.
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Exclusion Criteria:Children born at more than 37 weeks of gestation.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hsiu-LIn Chen | Contact | +886 0975355876 | ch840062@cc.kmu.edu.tw | |
| Pei-shih Chen | Contact | +886 0921813676 | pschen@gap.kmu.edu.tw |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Recruiting | Kaohsiung City | Taiwan |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D061808 | Air Filters |
| ID | Term |
|---|---|
| D005374 | Filtration |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D004864 | Equipment and Supplies |
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| Baseline and up to 3 weeks after intervention |
| D000091642 | Urogenital Diseases |