The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa

The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa

This study will evaluate the feasibility and acceptability of a household-based clean air intervention

A clean air intervention will be implemented in each household, including HEPA- based air filtration, solar lighting, and education. The air filtration system will be cycled monthly, with active filtration alternating with no filtration for one month on/one month off. To determine the effect of the clean air intervention within the household, PM2.5 concentration during each cycle and lung function will be measured among household members.

Inclusion Criteria:

• Age < 12 months

  • First episode of WHO-defined severe pneumonia22: cough or difficulty breathing with

• Oxygen saturation < 90% or central cyanosis,

• Severe respiratory distress, or

• Signs of pneumonia with a general danger sign

• Be willing to commit to entire 2 years of follow up visits.

• (Controls) Matched to each case on age (+/-1 month), sex, and community

Exclusion Criteria:

• Craniofacial, cardiac or other major malformation
• Neuromuscular condition that affects respiration
• Outside Smart Discharges Project catchment area
• Prior hospitalizations or known episodes of respiratory illness or episodes of pneumonia before index admission,