Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The objective of this study is to investigate the cardiopulmonary health effects of indoor air purification and different indoor environmental factors among school students in Beijing.
This randomized, double-blind crossover study was conducted to explore the cardiopulmonary effects of ionization air purification among 48 children in Beijing. Real or sham purification was performed in classrooms for 5 weekdays in a random order with a 2-month wash-out period. During the study periods, different indoor environmental factors were monitored including size-fractionated particulate matter (PM), black carbon (BC), ozone, carbon dioxide (CO2), negative air ions (NAI), noise, temperature and relative humidity, which were controlled as confounders in the analysis of the effects of indoor air purification. In addition, we analyzed the cardiopulmonary effects of those environmental factors on the children.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real purification | Active Comparator | Air purifier turned on |
|
| Sham purification | Sham Comparator | Air purifier turned off |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Air purifier | Other | active- or sham-mode air purifier used in 6 classrooms in a school with a crossover design |
|
| Measure | Description | Time Frame |
|---|---|---|
| Levels of lung function indicators | Lung function test was conducted including forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF). | 10 weekdays for intervention (active or sham) and 2 wash-out months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in autonomic cardiac function | Ambulatory electrocardiogram (ECG) was monitored including heart rate (HR) and heart rate variability (HRV). | 10 weekdays for intervention (active or sham) and 2 wash-out months |
| Level of respiratory inflammation |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Furong Deng, PhD&MD | Peking University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Pubic Health, Peking University | Beijing | Beijing Municipality | 100191 | China |
Not provided
| ID | Term |
|---|---|
| D011660 | Pulmonary Heart Disease |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D061808 | Air Filters |
| ID | Term |
|---|---|
| D005374 | Filtration |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D004864 | Equipment and Supplies |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Fractional exhaled nitric oxide (FeNO) test was conducted. |
| 10 weekdays for intervention (active or sham) and 2 wash-out months |
| Changes in ST-segment elevation | Ambulatory electrocardiogram (ECG) was monitored. | 10 weekdays for intervention (active or sham) and 2 wash-out months |
| Levels of oxidative stress in Exhaled Breath Condensate (EBC) | EBC was collected using a designated device for oxidative stress analysis. | 10 weekdays for intervention (active or sham) and 2 wash-out months |
| Levels of urinary metabolomics | Urine samples were collected for metabolomics analysis. | 10 weekdays for intervention (active or sham) and 2 wash-out months |