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The aim of the study is to evaluate osseous regenerative efficacy of eggshell derived nanohydroxyapatite in comparison with hydroxyapatite The test group includes patients with intrabony defects where flap surgery will be performed & Eggshell derived nano hydroxyapatite (ESnHA) is placed.
Experimental : Main treatment group Eggshell derived nano hydroxyapatite is placed into defect site Comparator : In patients allocated to control group, only Hydroxyapatite is placed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test group Eggshell derived nano hydroxyapatite | Experimental | In Test group after flap reflection & degranulation, bone graft i.e Eggshell derived nano hydroxyapatite is placed into defect. |
|
| Control group | Active Comparator | In Control group, after flap reflection & debridment bone graft i.e Hydroxyapatite is placed into defect. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eggshell derived nano hydroxyapatite | Other | Eggshell derived nano hydroxyapatite has high solubility and allows faster integration & replaces with osseous tissue |
|
| Measure | Description | Time Frame |
|---|---|---|
| RVG | Radiovisiography will be used to assess bone regeneration achieved post operatively | 3months & 6months |
| Probing Depth | 3 months & 6months | |
| Clinical Attachment Level | 3 months & 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Full mouth Plaque index | Full mouth plaque index was measured using Turesky modification of the Quigley-Hein Index at baseline, 3 months and 6 months | 3 months & 6 months |
| Full mouth Gingival index |
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Inclusion Criteria:
Presence of Two-walled or three-walled intrabony defects & Probing pocket depths (PPD) of >5mm after initial therapy Systemically healthy male and female patients of age >18 years
Exclusion Criteria:
Medically compromised patients Pregnant women, Heavy smokers, and Patients who underwent radiotherapy or chemotherapy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Svs Institute of Dental Sciences | Mahbūbnagar | Telangana | 509001 | India |
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| Hydroxyapatite | Other | Hydroxyapatite has similar chemical composition with crystalline structure of native bone |
|
Full mouth gingival index was measured using Loe & Silness Index at baseline, 3 months and 6 months
| 3 months & 6 months |
| ID | Term |
|---|---|
| D017886 | Durapatite |
| ID | Term |
|---|---|
| D006882 | Hydroxyapatites |
| D001031 | Apatites |
| D002130 | Calcium Phosphates |
| D010710 | Phosphates |
| D010756 | Phosphoric Acids |
| D017976 | Phosphorus Acids |
| D000148 | Acids, Noncarboxylic |
| D000143 | Acids |
| D007287 | Inorganic Chemicals |
| D017610 | Calcium Compounds |
| D008903 | Minerals |
| D017553 | Phosphorus Compounds |
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