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The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is:
Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers.
Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.
The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine [sCr], blood urea nitrogen [BUN], serum uric acid [sUA] and Glomerular Filtration Rate [GFR] and white blood cells (WBC) count and its specific subpopulations (neutrophils [NEU], lymphocytes [LYM], monocytes [MON], eosinophils [EOSI] and basophils [BASO]) were assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training group | Experimental | The training group underwent a moderate intensity intermittent walking training at 60% to 80% of the 6- min-walking-test distance, four times a week of 60 min/session for a period of 10 weeks. |
|
| Control group | No Intervention | No training intervention was intended for the control group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| walking intervention | Behavioral | Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week. |
| Measure | Description | Time Frame |
|---|---|---|
| serum creatinine | serum concentrations of creatinine (sCr) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| blood urea nitrogen | serum concentrations of blood urea nitrogen (BUN) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| serum uric acid | serum concentrations of uric acid (sUA) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| glomerular Filtration Rate | the glomerular Filtration Rate (GFR) has been computed using the Cockcroft formula, as follows: GFR (mL/min) = [(140 - age) × weight ×0.85]/(sCr× 72). | At baseline and at week 11(after the ten weeks of the training intervention). |
| white blood cells count | blood concentration of white blood cells (WBC) count were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany) | At baseline and at week 11(after the ten weeks of the training intervention). |
| neutrophils | blood concentration of neutrophils (NEU) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Body composition were determined, with barefoot and lightly dressed subjects, using a stadiometer (Holtain Ltd., UK) and an electronic scale (Tanita BC-533, Tokyo, Japan). | At baseline and after ten weeks of the training intervention. |
| 6 min walking test |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| High Institute of Sports and Physical Education of Kef | Boulifa | Kef Governorate | 7100 | Tunisia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42020262 | Derived | Abassi W, Ouerghi N, Muscella A, Marsigliante S, Bouassida A, Feki M, Weiss K, Knechtle B. Exercise-Induced Improvements in Renal and Inflammatory Markers in Postmenopausal Women With Obesity: A Randomized Study. Womens Health Issues. 2026 Apr 21:S1049-3867(26)00063-0. doi: 10.1016/j.whi.2026.03.006. Online ahead of print. |
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For confidentiality reasons, all data from this study are available upon request.
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| At baseline and at week 11(after the ten weeks of the training intervention). |
| lymphocytes | blood concentrations of lymphocytes (LYM) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). | At baseline and at week 11(after the ten weeks of the training intervention). |
| monocytes | blood concentration of monocytes (MON) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). | At baseline and at week 11(after the ten weeks of the training intervention). |
| eosinophils | blood concentrations of eosinophils (EOSI) ) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). | At baseline and at week 11(after the ten weeks of the training intervention). |
| basophils | blood concentration of basophils (BASO) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). | At baseline and at week 11(after the ten weeks of the training intervention). |
The 6-minute walk test was performed before and after the training intervention as an indicator of exercise capacity. |
| At baseline and after ten weeks of the training intervention. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |