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The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is:
Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors.
Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions).
Participants in control group will : not perform any physical training and maintain their usual daily activities.
This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MIWT group | Experimental | The MIWT group received moderate intensity intermittent walking training four times per week for 10 weeks. |
|
| Control group | No Intervention | The control group received no intervention for 10 weeks. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderate intensity intermittent walking training | Other | The intensity of the training is 60 to 80% of 6MWTdistance. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Thyroid hormones | Serum thyroid hormone concentrations are measured from a blood sample (5 ml) obtained from a prominent superficial vein in the antecubital region. | At baseline and after ten weeks of MIWT. |
| Body composition | Body composition was assessed using an electronic scale (Tanita BC-533, Tokyo, Japan), | At baseline and after ten weeks of MIWT. |
| Lipid profile | Measured by blood samples (5ml) from a prominent superficial vein in the antecubital region. | At baseline and after ten weeks of MIWT. |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic and diastolic blood pressure | Systolic and diastolic blood pressure measurements were conducted using an automatic blood pressure monitor (Omron BP652, Omron Healthcare Inc., Vernon Hills, IL, USA). | At baseline and after ten weeks of MIWT. |
| Heart rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| High Institute of Sports and Physical Education of Kef | Boulifa | Kef Governorate | 7100 | Tunisia |
For confidentiality reasons, all data from this study are available upon request.
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Heart rate was recorded after 10 minutes of relaxation in a seated position using an automatic blood pressure monitor (Omron BP652, Omron Healthcare Inc., Vernon Hills, IL, USA). |
| At baseline and after ten weeks of MIWT |
| 6 min walking test distance | It was recorded using the 6 min walking test. | At baseline and after ten weeks of MIWT |
| Perceived exertion rating | Perceived exertion rating (RPE) was assessed with the extensively validated RPE, a 15-point scale ranging from 6 ("no exertion at all") to 20 ("maximal exertion"). | At baseline and after ten weeks of MIWT. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |