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The goal of this clinical trial is to compare premenopausal and postmenopausal women regarding the effects of a 10-week moderate-intensity intermittent walking training (MIWT) program on aerobic capacity and selected cardiometabolic and inflammatory markers. The main question it aims to answer is: Does a MIWT program induce differential improvements in aerobic capacity, body composition, lipid profile, and inflammatory markers between premenopausal and postmenopausal women?
Participants in the premenopausal group will perform a 10-week MIWT program, three sessions per week. Participants in the postmenopausal group will perform the same 10-week MIWT program, three sessions per week. Each training session consists of 5 repetitions of 6-minute walking (6MWT) at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity (6-minute walk test), heart rate, blood pressure, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), and C-reactive protein (CRP) will be assessed before and after the intervention in both groups.
In premenopausal and postmenopausal women, differences in cardiometabolic profile, body composition, and aerobic capacity are commonly observed, with postmenopausal women generally presenting higher cardiometabolic risk. Regular physical activity is known to improve these parameters; however, the specific effects of moderate-intensity intermittent walking training (MIWT) on the comparison between premenopausal and postmenopausal women remain insufficiently explored.
The purpose of this study is to compare the effects of a 10-week moderate-intensity intermittent walking training (MIWT) program on aerobic capacity, body composition, cardiometabolic risk factors, and inflammatory markers in premenopausal and postmenopausal women.
Thirty-two women were allocated into a premenopausal group (n = 16) and a postmenopausal group (n = 16). Both groups performed a MIWT program three times per week for 10 weeks. Each training session consisted of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions.
Body composition, aerobic capacity (6MWT), heart rate, blood pressure, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), and C-reactive protein (CRP) were assessed before and after the intervention in both groups to evaluate changes induced by the training program.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Premenopausal Women Receiving MIWT Program | Experimental | Participants in the premenopausal group will perform a 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity, heart rate, blood pressure, lipid profile, and C-reactive protein will be assessed before and after the intervention. |
|
| Postmenopausal Women Receiving MIWT Program | Experimental | Participants in the postmenopausal group will perform the same 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. Body composition, aerobic capacity, heart rate, blood pressure, lipid profile, and C-reactive protein will be assessed before and after the intervention. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderate-Intensity Intermittent Walking Training (MIWT) | Behavioral | Participants will perform a 10-week moderate-intensity intermittent walking training (MIWT) program, with three supervised sessions per week. Each session consists of 5 repetitions of 6-minute walking (6-minute walk test, 6MWT) performed at 60-80% of the baseline 6MWT distance, interspersed by 6 minutes of active recovery between repetitions. The same intervention is applied to both premenopausal and postmenopausal women. |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index (BMI) | BMI calculated as weight (kg) divided by height squared (m²). | Baseline and after the 10 weeks of the training intervention. |
| Body Fat Percentage | Total body fat measured by digital scale (Tanita BC-533). | Baseline and after the 10 weeks of the training intervention. |
| Waist Circumference | Measured at the narrowest point between the rib cage and iliac crest using a tape measure. | Baseline and after the 10 weeks of the training intervention. |
| Hip Circumference | Measured at the widest point of the hips using a tape measure. | Baseline and after the 10 weeks of the training intervention. |
| C-Reactive Protein (CRP) | Serum CRP concentration (mg/L). | Baseline and after the 10 weeks of the training intervention. |
| Total Cholesterol | Serum total cholesterol concentration (mg/dL). | Baseline and after the 10 weeks of the training intervention. |
| High-Density Lipoprotein (HDL) Cholesterol | Serum HDL cholesterol concentration (mg/dL). | Baseline and after the 10 weeks of the training intervention. |
| Low-Density Lipoprotein (LDL) Cholesterol |
| Measure | Description | Time Frame |
|---|---|---|
| 6-Minute Walk Test (6MWT) Distance | Distance walked in 6 minutes on a 30-meter straight corridor. | Baseline and after the 10 weeks of the training intervention. |
| Blood Pressure (Systolic and Diastolic) |
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Inclusion Criteria:
Body mass index (BMI) > 24.9 kg/m².
Exclusion Criteria:
female
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wissal Abassi Dr | Contact | +21693304684 | wissalabassi93@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Wissal Abassi | Research Unit "Sport Sciences, Health and Movement"(UR22JS01) High Institute of Sport and Physical Education of Kef, University of Jendouba, 7100 Kef, Tunisia. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| High Institute of Sport and Physical Education of Kef, University of Jendouba | El Kef | Boulifa | 7100 | Tunisia |
For confidentiality reasons, all data from this study are available upon request.
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|
Serum LDL cholesterol concentration (mg/dL). |
| Baseline and after the 10 weeks of the training intervention. |
| Triglycerides | Serum triglyceride concentration (mg/dL). | Baseline and after the 10 weeks of the training intervention. |
Measured using an automated arm cuff (Omron BP652).
| Baseline and after the 10 weeks of the training intervention. |
| Resting Heart Rate | Measured using automated device (Omron BP652). | Baseline and after the 10 weeks of the training intervention. |