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The goal of this clinical trial is to investigate the impact of a walking training intervention program on liver enzymes and selected inflammatory markers in postmenopausal women with obesity. The main question it aims to answer is:
Does walking training reduce the risk of liver disease by modulating hepatic-enzymes and selected inflammatory markers? Researchers will compare walking training intervention (designed to the experimental group) to non-training intervention (designed to the control group) to see if the training program works to improve liver health in obese postmenopausal women.
Participants in the experimental (training) group will: underwent a moderate intensity intermittent walking training (MIWT) at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session.
Participants in control group will : not perform any physical training and maintain their usual daily activities.
Postmenopausal obesity is an important public health problem accompanied by increased systemic inflammation that escalates the risk of liver disease. Exercise improved inflammatory and hepatic function. Moderate-intensity intermittent-walking-training (MIWT) is the most feasible for obese-postmenopausal-women. This study aimed to investigate whether MIWT could reduce the risk by modulating hepatic-enzymes and selected inflammatory markers. Thirty-six sedentary obese postmenopausal women (mean age 55.7±3.5) were randomly divided into two groups: training group (TG, n=18) and control group (CG, n=18). The TG underwent a MIWT at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session. Body composition, hepatic (alanine-transaminase (ALT), aspartate-transaminase (AST), alkaline-phosphatase, gamma-glutamyl-transferase (GGT) and serum-bilirubin] and inflammatory markers [C-reactive-protein (CRP), and erythrocyte-sedimentation-rate (ESR)) were evaluated at baseline and after 10-week of protocol.](streamdown:incomplete-link)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training group | Experimental | The training group underwent a moderate intensity intermittent walking training at 60% to 80% of the 6-min-walking-test distance, four times a week of 60 min/session for a period of 10 weeks. |
|
| Control group | No Intervention | No training intervention was intended for this group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Walking training intervention | Behavioral | Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week. |
| Measure | Description | Time Frame |
|---|---|---|
| Alanine transaminase | Serum concentrations of alanine-transaminase (ALT) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| Aspartate transaminase | Serum concentrations of aspartate-transaminase (AST),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| Alkaline phosphatase | Serum concentrations of alkaline-phosphatase are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| Gamma glutamyl transferase | Serum concentrations of gamma-glutamyl-transferase (GGT),are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention) |
| Serum bilirubin | Serum concentrations of bilirubin are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). | At baseline and at week 11(after the ten weeks of the training intervention). |
| C reactive protein | Serum concentration of C-reactive-protein (CRP) are measured from a blood sample (5 ml). | At baseline and at week 11(after the ten weeks of the training intervention). |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Body composition were determined, with barefoot and lightly dressed subjects, using a stadiometer (Holtain Ltd., UK) and an electronic scale (Tanita BC-533, Tokyo, Japan). | At baseline and after ten weeks of the training intervention. |
| Aerobic capacity |
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Inclusion Criteria:
Women included are:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| High Institute of Sports and Physical Education of Kef | Boulifa | Kef Governorate | 7100 | Tunisia |
For confidentiality reasons, all data from this study are available upon request.
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| Erythrocyte sedimentation rate | Erythrocyte-sedimentation-rate (ESR) are measured from a blood sample (5 ml). | At baseline and at week 11(after the ten weeks of the training intervention). |
The 6-minute walk test was performed before and after the training intervention as an indicator of exercise capacity. |
| At baseline and after ten weeks of the training intervention. |