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The main goal of this study is to investigate how dihydrogen supplementation impacts body composition, appetite, quality of life specific to obesity, and levels of the hormone GLP-1 in men and women with obesity. This randomized controlled trial aims to explore whether dihydrogen can improve these health indicators.
The primary aim of this randomized controlled trial is to evaluate the effects of dihydrogen supplementation on body composition indices, appetite, obesity-specific quality of life, and circulating GLP-1 levels in obese men and women
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hydrogen-rich water | Experimental | One liter per day of hydrogen rich water |
|
| Control water | Placebo Comparator | One liter per day of tap water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary Supplement: Hydrogen-rich water | Dietary Supplement | Hydrogen-rich water with 12 mg of hydrogen per serving |
|
| Measure | Description | Time Frame |
|---|---|---|
| Appetite | Total scores for appetite as assessed by the the Food Cravings Questionnaire (FCQ) | Change from baseline appetite at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Obesity-related quality or life | Total scores for obesity-related quality of life as assessed by the The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire | Change from baseline total scores for obesity-related quality of life at 8 weeks |
| Body fat |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Applied Bioenergetics Lab | Novi Sad | Vojvodina | 26000 | Serbia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37560746 | Background | Korovljev D, Ostojic J, Todorovic N, Ostojic SM. Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans. Arch Med Sci. 2023 Jul 13;19(4):1151-1153. doi: 10.5114/aoms/162938. eCollection 2023. | |
| 40731927 | Derived | Todorovic N, Baltic S, Nedeljkovic D, Kuzmanovic J, Korovljev D, Javorac D, Bijelic K, Kladar N, Tarnava A, Ostojic SM. The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial. Medicina (Kaunas). 2025 Jul 18;61(7):1299. doi: 10.3390/medicina61071299. |
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Data obtained through this study may be provided to qualified researchers with academic interest in obesity. Data will be coded, with no PHI included. Approval of the request and execution of all applicable agreements are prerequisites to the sharing of data with the requesting party.
Data requests can be submitted starting 9 months after article publication and the data will be made accessible for up to 24 months. Extensions will be considered on a case-by-case basis.
Data obtained through this study may be provided to qualified researchers with academic interest in obesity.
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Dietary Supplement: Control water | Dietary Supplement | Control water with 0 mg of hydrogen per serving |
|
Percentage of body fat as assessed by a multifrequency bioelectrical impedance analyzer |
| Change from baseline body fat at 8 weeks |
| Serum GLP-1 | Serum levels of glucagon-like peptide-1 (GLP-1) | Change from baseline GLP-1 at 8 weeks |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |