Medium-term Effects of Molecular Hydrogen on Metabolic Fitness in Obesity

Medium-term Effects of Molecular Hydrogen on Metabolic Fitness in Obesity

Molecular hydrogen (H2) effectively tackles obesity-related disorders in animal models yet no studies so far investigated the effectiveness of H2 for improving biomarkers of obesity in humans. In this double blind, placebo-controlled, crossover pilot trial, the investigators will evaluate the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in middle age overweight women, with hydrogen administered orally for 4 weeks.

Inclusion Criteria:

• age > 55 years
• body mass index > 25 kg/m2

Exclusion Criteria:

• no history of H2 supplementation within the 4 weeks before study commenced
• no major chronic diseases, as evaluated by pre-participation health screening and clinical chemistry