Hydrogen-Rich Water and Resting Metabolism in Young Adults

Effects of Hydrogen-Rich Water on Resting Metabolism in Healthy Young Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial

The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The study aims to assess whether acute HRW intake can modulate metabolic rate and fuel preference at rest, and to explore inter-individual variability in response.

Inclusion Criteria:

• Aged 18-35 years
• BMI between 18.5 and 25.0 kg/m²
• Apparently healthy, with no history of chronic disease
• Non-smoker, not currently using nicotine-containing products
• Able to provide informed consent
• Willing to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each study visit
• Able to comply with study procedures, including fasting and attending all study visits

Exclusion Criteria:

• Diagnosed metabolic, cardiovascular, respiratory, gastrointestinal, or endocrine disorders
• Use of dietary supplements or medications affecting metabolism (within the past 2 weeks)
• Allergy or intolerance to components of the hydrogen or placebo beverages
• Pregnant or lactating
• Shift work or irregular sleep schedule
• Participation in another clinical study within the past 30 days