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The study objectives are to assess over the gliclazide MR-SGLT2i combined treatment course in patients with T2DM adding SGLT2i to gliclazide MR-based therapy.
The primary objective is to determine the effectiveness of adding SGLT2i to gliclazide MR-based therapy in patients with T2DM, as measured by HbA1c changes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| population description | adult patients with T2DM who initiated add-on SGLT2i treatment to gliclazide MR 60 mg, in routine practice |
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| Measure | Description | Time Frame |
|---|---|---|
| effectiveness of adding SGLT2i to gliclazide MR | To determine the effectiveness of adding SGLT2i to gliclazide MR-based therapy in patients with T2DM, as measured by HbA1c changes (in %) | from index date (date of SGLT2i adding to gliclazide MR) to discontinuation of the combination (at least 2 months) or date of data collection initiation during the eligibility period, loss to follow-up, or death, whichever occurs first (approx 2 months) |
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Inclusion Criteria:
Exclusion Criteria:
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Male and female who are treated by Gliclazide MR 60 at index date and who started with SGLT2i added to gliclazide MR with a minimum of 60 days of these combined treatments during the eligibility period
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Servier Affaires Médicales | Suresnes | 92284 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41175321 | Derived | Moreira RO, Nicodemus NA Jr, Comlekci A, Yu M, Almalki MH. ADD2Dia: Real-World Clinical Effectiveness of Adding a Sodium-Glucose Cotransporter 2 Inhibitor to Gliclazide-Based Therapy in Type 2 Diabetes. Adv Ther. 2025 Dec;42(12):6295-6309. doi: 10.1007/s12325-025-03394-2. Epub 2025 Nov 1. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| D004700 | Endocrine System Diseases |