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Inhibitors of the type 2 sodium-glucose co-transporter (iSGLT2) may improve the metabolic and hemodynamic profile in patients with DM2 and heart failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Patients with diabetes and heart failure that are treated with iSGLT2 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| iSGTL2 | Drug | Treatment with empaglifozine 10 mg/day (may be also dapaglifozine 10mg/day depending on clinical trial results) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiac biomarkers | Changes in cardiac biomarkers: NTproBNP, CA125 and ST2 | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in quality of life: EuroQol-5D questionnaire (EuroQol five dimension questionnaire) | Changes in patient's quaility of life by 5Q questionnaire (EuroQol standardised, non-disease-specific instrument for health-related quality of life with 2 parts: first one score from 3-3-3-3 (worst) to 1-1-1-1 (best) and second one which a visual scale scores form 0 (worst)-100 (best). EuroQol-a new facility for the measurement of health-related quality of life. Health Policy 1990;16:199-208. El EuroQol-5D: una alternativa sencilla para la medición de la calidad de vida relacionada con la salud en atención primaria. Aten Primaria 2001; 28:425-429.) |
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Inclusion Criteria:
Exclusion Criteria:
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Consecutive patients with type 2 diabetes and heart failure who attend a university hospital heart failure unit.
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| Name | Affiliation | Role |
|---|---|---|
| Nuria Alonso Pedrol | Germans Trias i Pujol Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Germans Trias i Pujol University Hospital | Badalona | Spain |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| 12 months |
| Improvement of pulmonary congestion | Changes in pulmonary congestion by pulmonary echocardiography | 12 months |
| Improve in the 6-minute walk | Changes in functional capacity by the 6 minute-walk | 12 months |
| D009750 |
| Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |