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The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on pulmonary arterial pressure (PAP) assessed at 3200 m.
Highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA (Tricuspid Regurgitation Pressure Gradient) >30 mmHg will be recruited for this project. Highlanders permanently living at HA >2500 m will have echocardiografy to assess PAP near their living altitude in Aksay at 3200 m with and without 10L/min supplemental oxygen therapy (SOT) via face mask.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ambient air | Active Comparator | Highlanders with HAPH will perform the echocardiography on ambient air at 3200m |
|
| 10 L/min SOT through face mask | Experimental | Supplemental oxygen therapy (SOT) at 10 L/min will be provided via face mask from oxygen concentrators |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Other | Echocardiography will be performed according to clinical standards |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pulmonary Artery Pressure with SOT vs.ambient air at 3200m | Change in RV/RA in mmHg assessed by echocardiography with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Cardiac Output with SOT vs. ambient air at 3200m | Change in cardiac output (l/min) assessed by echocardiography with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Change in right to left heart diameter ratio with SOT vs.ambient air at 3200m |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Talant MA Sooronbaev, Prof. Dr. | National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | Principal Investigator |
| Silvia Ulrich, Prof. Dr. | University Hospital Zurich, Department of Pulmonology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aksay Medical Center | Aksay Plateau, Naryn, Kyrgyzstan | Kyrgyzstan |
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Each highlander with HAPH will perform a echocardiography with and without SOT according to a cross-over design
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Change in right to left heart diameter ratio assessed by echocardiography with SOT compared to ambient air at 3200m |
| at 15 min of breathing ambient air or supplemental oxygen |
| Change in tricuspid annular plane systolic excursion (TAPSE) with SOT vs.ambient air at 3200m | Change in tricuspid annular plane systolic excursion (TAPSE) with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Change in right atrial area with SOT vs. ambient air at 3200m | Change in right atrial area by echocardiography with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Change in right heart strain with SOT vs. ambient air at 3200m | Change in right heart strain by echocardiography with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Change in pH by arterial blood gases with SOT vs. ambient air at 3200m | Changes in pH by arterial blood gases with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Change in PaO2 by arterial blood gases with SOT vs. ambient air at 3200m | Changes in PaO2 by arterial blood gases with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| Change in PaCO2 by arterial blood gases with SOT vs. ambient air at 3200m | Changes in PaCO2 by arterial blood gases with SOT compared to ambient air at 3200m | at 15 min of breathing ambient air or supplemental oxygen |
| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
| D006976 | Hypertension, Pulmonary |
| D000860 | Hypoxia |
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
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