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| Name | Class |
|---|---|
| National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | OTHER_GOV |
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Exposure to high altitudes, defined as locations above 2500 m, has been shown to cause cognitive alternations due to reduced blood oxygenation (SpO2). However, it remains to be determined whether cognitive changes are present in highlanders living at moderate altitudes (2500 m) and whether cognitive alterations are reversible with supplemental oxygen therapy (SOT).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SOT followed by Sham intervention | Active Comparator | 5L /min supplemental oxygen therapy through a nasal canula will be administered to the participants. The intervention will start 5 minutes before the neurocognitive assessments and will be administered throughout the assessment. After >4 hours of washout, the participants will repeat the neurocognitive assessments with 5 L/min sham intervention (room air). |
|
| Sham intervention followed by SOT | Sham Comparator | 5L /min sham intervention (room air) through a nasal canula will be administered to the participants. The intervention will start 5 minutes before the neurocognitive assessments and will be administered throughout the assessment. After >4 hours of washout, the participants will repeat the neurocognitive assessments with 5 L/min supplemental oxygen therapy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supplemental oxygen therapy | Drug | 5 L/min supplemental oxygen therapy administered through nasal canula. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Psychomotor vigilance reaction time | The difference in the reaction time during a 10-minute psychomotor vigilance test between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Trail making test performance | The difference in the trial making test A performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| Stroop test performance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Furian, Prof. Dr. | Contact | +41794037586 | michael.furian@usz.ch | |
| Edith M Schneider, Dr. | Contact | edith.schneidergasser@usz.ch |
| Name | Affiliation | Role |
|---|---|---|
| Michael Furian | University of Zurich | Principal Investigator |
| Edith M Schneider, Dr. | University of Zurich | Principal Investigator |
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| ID | Term |
|---|---|
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D010100 | Oxygen |
| ID | Term |
|---|---|
| D018011 | Chalcogens |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |
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| Sham intervention | Other | 5 L/min sham intervention administered through nasal canula. |
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The difference in the stroop test performance between SOT and Sham intervention.
| Comparison between SOT and sham after 15 minutes intervention |
| Digit Span test performance | The difference in the digit span test performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| Go / No-Go test performance | The difference in the Go / No-Go test performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| N-back test performance | The difference in the n-back test performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| Task Switching Cued test performance | The difference in the task switching cued test performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| Flanker test performance | The difference in the Flanker test performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |
| Corsi Span test performance | The difference in the Corsi span test performance between SOT and Sham intervention. | Comparison between SOT and sham after 15 minutes intervention |