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Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mother-infant cohort with antibiotic treatment group | E.g., Bacterial infection during pregnancy |
| |
| Mother-infant cohort (Prophylactic antibiotics therapy) | E.g., cesarean section |
| |
| Mother-infant cohort (Natural delivery) | E.g., Natural delivery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antibiotic treatment | Other | AT: Mother-infant cohort with antibiotic treatment group CS: Mother-infant cohort (Prophylactic antibiotics therapy) ND: Mother-infant cohort (Natural delivery) |
| Measure | Description | Time Frame |
|---|---|---|
| Infant gut microbiome |
| Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Antibiotic treatment |
| Pregnancy (12, 24, 37 weeks) and infants (born, 1 week, and 1, 3, 6, 12 months) |
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Inclusion Criteria:
Pregnant woman
Newborn
Exclusion Criteria:
-
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Pregnant woman registered in Peking University People's Hospital will plan to give birth in the hospital.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Peking University People's Hospital | Recruiting | Beijing | China |
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Umbilical cord blood, placenta, stool