Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Zhongshan Bo Ai Hospital | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
This study is planned to be recruited in two hospitals in South China, Zhujiang Hospital of Southern Medical University and Zhongshan Boai Hospital Recruit participants, plan to recruit obstetrics and child health departments in study hospitals, meet inclusion and discharge criteria 1~3 infants, a total of 360, recruited by Pearl River Hospital of Southern Medical University and Zhongshan Boai Hospital 180 people each.
This is a case-control study. By collecting fecal samples of infants and young children in the observation group and control group at different time points (0~1 years old, 1~2 years old, 2~3 years old), the intestinal flora of infants and young children was detected by 16S rDNA sequencing, and fecal calprotectin (CP) and secretory IgA (SIgA) were detected by ELISA. To study the effects of exposure factors on intestinal flora and immunity in offspring.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Reproductive tract GBS colonization group of mothers during pregnancy | Reproductive tract GBS colonization group of mothers during pregnancy，Use of antibiotics |
| |
| No reproductive tract GBS colonization group in mothers during pregnancy | No reproductive tract GBS colonization group in mothers during pregnancy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antibiotics | Drug | Reproductive tract GBS colonization group of mothers during pregnancy，Use of antibiotics |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intestinal flora | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome. | Fecal samples of infants and young children in the observation group and control group at different time points (0~1 years old) of offspring were collected |
| Secretory IgA | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring. | Fecal samples of infants and young children in the observation group and control group at different time points (0~1 years old) of offspring were collected |
| Calprotectin | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the cailprotectin of offspring. | Fecal samples of infants and young children in the observation group and control group at different time points (0~1 years old) of offspring were collected |
| Measure | Description | Time Frame |
|---|---|---|
| Intestinal flora | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome. | Fecal samples of infants and young children in the observation group and control group at different time points 1~2 years of offspring were collected |
| Secretory IgA |
| Measure | Description | Time Frame |
|---|---|---|
| Intestinal flora | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome. | Fecal samples of infants and young children in the observation group and control group at different time points 2~3 years old of offspring were collected |
| Secretory IgA |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Infants: 37-41 weeks of age, born through vaginal delivery, 2500g<= birth weight < 4000g, 0-3 years of age; 2. The mother: birth ranging in age from 18 to 40 years old, the single pregnancy, pregnancy 35 - 41 weeks to complete the GBS screening; 3. The guardian agrees to participate in the study voluntarily.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Qian Wang | Southern Medical University, China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhujiang Hospital | Guangzhou | Guangdong | 510000 | China |
Not provided
| ID | Term |
|---|---|
| D000900 | Anti-Bacterial Agents |
| ID | Term |
|---|---|
| D000890 | Anti-Infective Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
Not provided
Not provided
Not provided
Not provided
Not provided
|
Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring. |
| Fecal samples of infants and young children in the observation group and control group at different time points 1~2 years of offspring were collected |
| Calprotectin | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the cailprotectin of offspring. | Fecal samples of infants and young children in the observation group and control group at different time points 1~2 years of offspring were collected |
Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring. |
| Fecal samples of infants and young children in the observation group and control group at different time points 2~3 years old of offspring were collected |
| Calprotectin | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring. | Fecal samples of infants and young children in the observation group and control group at different time points 2~3 years old of offspring were collected |