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| Name | Class |
|---|---|
| Zhongshan Bo Ai Hospital | OTHER |
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In view of the current status of prevention and research on GBS disease in mothers and infants at home and abroad, this project intends to explore the characteristics of vaginal microbiota of GBS-colonized pregnant women in southern China, the impact of IAP prevention of GBS-EOD on vaginal flora, and the effect of IAP prevention of GBS-EOD on intestinal flora and immune production in offspring, so as to improve the ability to prevent and treat GBS-related diseases in mothers and infants and promote maternal and infant health.
This project intends to explore the characteristics of vaginal microbiota of GBS-colonized pregnant women in southern China, the impact of IAP prevention of GBS-EOD on vaginal flora, and the effect of IAP prevention of GBS-EOD on intestinal flora and immune production in offspring, so as to improve the ability to prevent and treat GBS-related diseases in mothers and infants and promote maternal and infant health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pregnant women colonized by Group B Streptococcus (GBS) and undergoing IAP | vaginal microbiome of pregnant women colonized by Group B Streptococcus (GBS)、Pregnant women undergoing IAP |
| |
| pregnant women does not colonized by Group B Streptococcus (GBS) and not undergoing IAP | Group B streptococcus (GBS) does not colonize the vaginal microbiome of pregnant women、Pregnant wome |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| antibiotic | Drug | For pregnant women with GBS colonization, antibiotics are used to prevent infection |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intestinal flora | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome of offspring. | The offspring are born on the 3rd day after birth |
| Secretory IgA | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring. | The offspring are born on the 3rd day after birth |
| Calprotectin | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the cailprotectin of offspring. | The offspring are born on the 3rd day after birth |
| Intestinal flora | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome of offspring. | The offspring are born on the 42nd day after birth |
| Secretory IgA | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring. | The offspring are born on the 42nd day after birth |
| Calprotectin | Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the cailprotectin of offspring. | The offspring are born on the 42nd day after birth |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of IAP to prevent GBS-EOD. | Analyze the effect of IAP (intrapartum antibiotics prophylaxis) to prevent GBS-EOD on maternal vaginal microbiome. | Vaginal flora on days 3rd after delivery. |
| The characteristics of vaginal microbiome of pregnant women. |
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Inclusion Criteria:
Exclusion Criteria:
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1. Pregnant women are 18 to 40 years; 2. 35 to 41 weeks of pregnancy
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| Name | Affiliation | Role |
|---|---|---|
| Qian Wang | Southern Medical University, China | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhujiang Hospital | Guangzhou | Guangdong | 510280 | China |
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| ID | Term |
|---|---|
| D000900 | Anti-Bacterial Agents |
| ID | Term |
|---|---|
| D000890 | Anti-Infective Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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Analyze the characteristics of vaginal microbiome of pregnant women colonized by Group B Streptococcus (GBS). |
| Vaginal flora on days 3rd after delivery. |
| The effect of IAP to prevent GBS-EOD. | Analyze the effect of IAP (intrapartum antibiotics prophylaxis) to prevent GBS-EOD on maternal vaginal microbiome. | Vaginal flora on days 42nd after delivery. |
| The characteristics of vaginal microbiome of pregnant women. | Analyze the characteristics of vaginal microbiome of pregnant women colonized by Group B Streptococcus (GBS). | Vaginal flora on days 42nd after delivery. |