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The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function. Dysbiosis of gut microbiota has been linked with obesity, hyperglycemia, hyperlipidemia, inflammatory bowel disease and other chronic inflammatory diseases. Gut microbiota is affected by host genetic markup, diet and life style; and therefore varied by human races and geographical locations.
The development of gut microbiota starts before birth. The infant's microbiome can impact on human health in later life. The microbiome of pregnant women are associated with early-life microbiota of their offspring as well as growth, neurodevelopment and the development of allergic and neurocognitive disorders.
Early childhood, when the microbiota is less mature and more malleable, is a golden age for microbiota manipulation to prevent disease. Studying microbiota at this golden age also allow us to dissect the development of a faulty microbiota and identify therapeutic targets to reverse it and cure diseases that are already developed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women | Women who are being pregnant and plan to give birth in local hospital. Pregnant women who plan to stay in the same local area for at least 7 years post-delivery. | ||
| New Born Baby | new born baby of an enrolled pregnant woman. | ||
| Father of new born baby | Biological father of an enrolled new born baby. |
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| Measure | Description | Time Frame |
|---|---|---|
| Develop a 100,000 pair of mother-baby longitudinal cohort | Set up a large scale database to collect data such as comprehensive clinical data, such as mother's and father's demographic and clinical information (e.g. age, weight, gender, family medical history, dietary, drug usage etc.) | 8 year |
| Measure | Description | Time Frame |
|---|---|---|
| Dissect the important microbiome that maintain health | Study samples will be collected to characterize which microbiota will be transmitted from mother to baby by performing metagenomics of gut microbiome in stool and other samples | 8 year |
| Seize the golden period of early life for prevention of human diseases |
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Pregnant women
Inclusion Criteria:
New Born Baby Inclusion Criteria
Father of new born baby Inclusion Criteria
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This project will consist of a total 100,000 mother-baby pairs from all centers in 7 years. The study is exploratory in nature. In considering the number of events required for reliable quantification of different factors on a range of diseases, we decided to include 100,000 mother-baby pairs.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jessica Ching | Contact | +852 26373260 | jessicaching@cuhk.edu.hk | |
| Kitty Cheung | Contact | +852 26373260 | kittyccy@cuhk.edu.hk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prince of Wales Hospital | Recruiting | Hong Kong | Hong Kong | China |
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Blood, urine, stool, saliva, hair, nail, nasopharyngeal swab, skin swab, buccal swab, placenta, cord blood, low Vaginal swab and breast milk samples
Study samples will be collected to characterize which microbiota induces disease by performing metagenomics of gut microbiome in stool and other samples and develop treatment with microbiota. |
| 8 year |