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The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants treated with antibiotics.
This study aims to examin the impact of probiotics under 2 separate conditions, probiotics concurrent administration with antibiotic and probiotics administration during the recovery phase.Birth,7 days,14 days(or 21 days) and 42 days data will be collected and put into analysis to provide somes suggestions on the probiotics use in the clinical for the infants treated with antibiotics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| antibiotics | No Intervention | the patients in this arm will not receive probiotics. | |
| probiotics concurrent with antibiotic | Experimental | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis for 2 weeks concurrent with antibiotic. |
|
| probiotics after antibiotic | Experimental | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis for 2 weeks after antibiotic. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotics | Dietary Supplement | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis with does of 1.5*10^7CFU for 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change from birth,7 days,14 days(or 21 days) on gut mcrobiome at 42 days | change of the gut mcrobiome will be calculated at 42 days in comparison with birth,7 days,14 days(or 21 days) | 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| change from birth on gut mcrobiome at 7 days | change of the gut mcrobiome will be calculated at 7 days in comparison with baseline | 7 days |
| change from birth and 7 days on gut mcrobiome at 14 days(or 21 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yang Rong, MD | Contact | 13321917107 | leexuechun1@126.com | |
| Hui Zhong, MD | Contact | 13701806709 | zhonghuiunique@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Huanlong Qin | Shanghai 10th People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai 10th People's Hospital | Recruiting | Shanghai | Shanghai Municipality | 200072 | China |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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change of the gut mcrobiome will be calculated at 14(or 21 days) in comparison with birth and 7 days
| 14 days（or 21days） |
| D019602 |
| Food and Beverages |