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The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of infants with jaundice.
This study aims to examin the impact of probiotics administration during the process of infants jaundice treatment and recovery phase.the recovery phase.Birth,7 days,14 days and 42 days data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the infants with jaundice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| blue light phototherapy | No Intervention | the patients in this arm will not receive probiotics. | |
| probiotics concurrent with phototherapy | Experimental | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis for 2 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotics | Dietary Supplement | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus, Enterococcus faecalis with does of 1.5*10^7CFU for 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| change from birth,7 days,14 days on gut microbiome at 42 days by 16S rRNA | change of the gut microbiome will be calculated at 42 days in comparison with birth,7 days,14 days | 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| change from birth on gut microbiome at 7 days by 16S rRNA | change of the gut microbiome will be calculated at 7 days in comparison with baseline | 7 days |
| change from birth and 7 days on gut microbiome at 14 days by 16S rRNA |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rong Yang, MD | Contact | 13321917107 | leexuechun1@126.com | |
| Hui Zhong | Contact | 13701806709 | zhonghuiunique@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Huanlong Qin | Shanghai 10th People's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai 10th People's Hospital | Recruiting | Shanghai | 20072 | China |
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| ID | Term |
|---|---|
| D007565 | Jaundice |
| ID | Term |
|---|---|
| D006932 | Hyperbilirubinemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012877 | Skin Manifestations |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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change of the gut microbiome will be calculated at 14 days in comparison with birth and 7 days
| 14 days |
| D012816 | Signs and Symptoms |
| D019602 |
| Food and Beverages |