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| Name | Class |
|---|---|
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
| Colorado State University | OTHER |
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Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use. High doses of THC have not been well-studied in the laboratory, and it is unclear how high doses of THC may impact alcohol consumption patterns. The proposed study will explore the effects of oral THC (20mg dronabinol) vs. placebo on neural reward, alcohol self-administration and naturalistic co-use patterns.
Participants will undergo a screening assessment, baseline session and two laboratory visits. The laboratory visits will involve an MRI scan and the opportunity to consume alcohol in our BAR lab. Prior to the MRI, participants will consume, a placebo (0mg) or high (20mg) dose of oral THC (dronabinol). Visits will be separated by 7 to 14 days. Dronabinol is an FDA-approved product that will be dispensed by our on-campus pharmacy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo first, Dronabinol second | Experimental | This arm will receive placebo on the first visit, and dronabinol on the second visit |
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| Dronabinol first, Placebo second | Experimental | This arm will receive dronabinol on the first visit, and placebo on the second visit. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dronabinol Pill | Drug | Dronabinol 20 mg |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in alcohol cue-elicited brain activation (fMRI) between medication periods | Alcohol cue reactivity task BOLD signal to alcohol cues, relative to neutral beverage cues | 1 hour after administration of a single dose of study medication at 7 days, 14 days. |
| Change in cannabis cue-elicited brain activation (fMRI) between medication periods | Cannabis cue reactivity task BOLD signal to cannabis cues, relative to neutral cues | 1 hour after administration of a single dose of study medication at 7 days, 14 days. |
| Alcohol self-administration | Number of drinks self-administered | 3-4 hours after administration of a single dose of study medication at 7 days, 14 days. |
| Self-reported alcoholic drinks consumed | # of drinks consumed per day | one report per day for the 14 days after the final laboratory visit on day 14. |
| Self-reported cannabis use | Amount of cannabis consumed per day | One report per day for the 14 days after the final laboratory visit on day 14 |
| Self-reported cannabis and alcohol co-use | Number of days in which cannabis and alcohol were both used | One report per day for the 14 days after the final laboratory visit on day 14. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elnaz Nourollahimoghadam | Contact | 3037246020 | elnaz.nourollahimoghadam@cuanschutz.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Recruiting | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D013759 | Dronabinol |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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| Placebo | Drug | placebo |
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